粟酒裂殖酵母辐射敏感性的遗传控制
Genetic control of radiation sensitivity in Schizosaccharomyces pombe.
作者信息
Nasim A, Smith B P
出版信息
Genetics. 1975 Apr;79(4):573-82. doi: 10.1093/genetics/79.4.573.
Abstract
Genetic analysis of a large number of radiation-sensitive mutants of S. pombe, isolated in different laboratories, showed that these isolates represent 22 non-allelic loci. The mutants were shown to fall into three distinct classes concerning response to UV and ionizing radiation, including two mutants which are primarily sensitive to ionizing radiation but not to UV. Single-gene mutants were crossed to obtain supersensitive double mutants. Such double mutants showed a marked increase in sensitivty to a variety of inactivating agents as compared to the parental strains. The isolation of three classes of radiation-sensitive mutants and the construction of double mutants implies the presence of multiple pathways in S. pombe for repair of radiation-induced damage. The bearing of these data on cellular repair mechanisms in eukaryotes is discussed.
摘要
对在不同实验室分离出的大量粟酒裂殖酵母辐射敏感突变体进行的遗传分析表明，这些分离株代表22个非等位基因座。这些突变体在对紫外线和电离辐射的反应方面可分为三个不同类别，其中包括两个主要对电离辐射敏感但对紫外线不敏感的突变体。将单基因突变体进行杂交以获得超敏感双突变体。与亲本菌株相比，此类双突变体对多种灭活剂的敏感性显著增加。三类辐射敏感突变体的分离以及双突变体的构建表明，粟酒裂殖酵母中存在多种修复辐射诱导损伤的途径。本文讨论了这些数据与真核生物细胞修复机制的关系。
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