支气管哮喘患者在变应原和运动激发后尿白三烯E4水平

Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma.

作者信息

Smith C M, Christie P E, Hawksworth R J, Thien F, Lee T H

机构信息

Department of Allergy and Allied Respiratory Disorders, Guy's Hospital, London, United Kingdom.

出版信息

Am Rev Respir Dis. 1991 Dec;144(6):1411-3. doi: 10.1164/ajrccm/144.6.1411.

DOI:10.1164/ajrccm/144.6.1411

PMID:1660231

Abstract

Urinary leukotriene E4 (LTE4) concentrations were measured in six asthmatic subjects after treadmill exercise, and in five asthmatic subjects after allergen challenge. Exercise and allergen challenge produced a 42 +/- 18% (mean +/- SD) and 22 +/- 8% fall in FEV1, respectively. The baseline concentration of urinary LTE4 in subjects challenged with exercise was 64 (27 to 150) pg/mg creatinine (geometric mean and 95% confidence interval), and in those challenged with allergen it was 36 (23 to 59) pg/mg creatinine. Urinary LTE4 concentrations did not change significantly in the 24 h after exercise. In contrast, there was a mean 4-fold increase in urinary LTE4 during the 3 h after allergen challenge.

摘要

在六名哮喘患者进行跑步机运动后以及五名哮喘患者进行过敏原激发后，测量了尿白三烯E4（LTE4）浓度。运动和过敏原激发分别使第一秒用力呼气量（FEV1）下降了42±18%（平均值±标准差）和22±8%。运动激发组患者尿LTE4的基线浓度为64（27至150）pg/mg肌酐（几何平均值和95%置信区间），过敏原激发组为36（23至59）pg/mg肌酐。运动后24小时内尿LTE4浓度无显著变化。相比之下，过敏原激发后3小时内尿LTE4平均增加了4倍。