Cui Lei, Jing Shicong, Wang Xiangfen, Zong Qiang, Li Xiao, Jiao Chunxiao, Peng Lei, Liu Lin, Xu Xinmiao, Niu Mingfeng
Department of Cardiology, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
Department of Geriatrics, Yantai Yeda Hospital Affiliated to Binzhou Medical University Yantai 264006, Shandong, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17461-70. eCollection 2015.
Despite large numbers of studies from Chinese population related to the association between rs5498 polymorphism and coronary heart disease (CHD) risk, the results are inconsistent probably due to the difference in the nationalities. To further evaluate the impact of the rs5498 polymorphism on CHD risk of different nationalities population, we performed this meta-analysis. We comprehensively searched the eligible studies for the present meta-analysis through China National Knowledge Infrastructure (CNKI), PubMed, EMBASE databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained to evaluate the strength of the association between rs5498 polymorphism and CHD risk. Finally, a total of 18 studies including 5537 subjects met the inclusion criteria. The pooled result showed that the rs5498 polymorphism was significantly associated with an increased risk of CHD in allele comparison model (OR=1.43, 95% CI=1.17-1.73, P=0.000), homozygote model (OR=1.23, 95% CI=1.03-1.46, P=0.000), heterozygote model (OR=1.23, 95% CI=1.03-1.46, P=0.018), dominant model (OR=1.45, 95% CI=1.21-1.74, P=0.001) and recessive model (OR=2.17, 95% CI=1.70-2.77, P=0.002). But subgroup analysis only supported the results from data of Han and Zhuang population in South China and North China. We did not find any evidences revealing some relationship between them in the Uygur population of Northwest China. Totally, the results of our meta-analysis indicate that the rs5498 polymorphism may be associated with coronary heart disease in Han and Zhuang population but not in Uyghur population. A large number of well-designed and multiracial studies should be conducted to re-evaluate the relationship.
尽管有大量来自中国人群的关于rs5498基因多态性与冠心病（CHD）风险关联的研究，但结果不一致，这可能是由于种族差异所致。为了进一步评估rs5498基因多态性对不同种族人群冠心病风险的影响，我们进行了这项荟萃分析。我们通过中国知网（CNKI）、PubMed、EMBASE数据库全面检索了符合本荟萃分析条件的研究。获得合并优势比（OR）和95%置信区间（CI）以评估rs5498基因多态性与冠心病风险之间关联的强度。最后，共有18项研究、5537名受试者符合纳入标准。合并结果显示，在等位基因比较模型（OR = 1.43，95% CI = 1.17 - 1.73，P = 0.000）、纯合子模型（OR = 1.23，95% CI = 1.03 - 1.46，P = 0.000）、杂合子模型（OR = 1.23，95% CI = 1.03 - 1.46，P = 0.018）、显性模型（OR = 1.45，95% CI = 1.21 - 1.74，P = 0.001）和隐性模型（OR = 2.17，95% CI = 1.70 - 2.77，P = 0.002）中，rs5498基因多态性与冠心病风险增加显著相关。但亚组分析仅支持来自中国南方和北方汉族及壮族人群数据的结果。在中国西北维吾尔族人群中，我们未发现任何表明它们之间存在某种关系的证据。总体而言，我们的荟萃分析结果表明，rs5498基因多态性可能与汉族和壮族人群的冠心病有关，但与维吾尔族人群无关。应开展大量设计良好的多种族研究以重新评估这种关系。
