Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Biosci Rep. 2019 May 17;39(5). doi: 10.1042/BSR20190554. Print 2019 May 31.
Yin et al. ( (2019) , BSR20180923) recently published a meta-analysis about the association between the K469E (rs5498) polymorphism and risk of coronary heart disease (CHD). Authors included 14 studies based on their inclusion criteria. They indicated that only studies which their genotyping data were in Hardy-Weinberg equilibrium (HWE) were included in their meta-analysis. They also tested HWE for these studies and found all the control groups in HWE. As their main finding, they concluded that 'K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD amongst Chinese and Caucasians populations'. However, there seems to be presenting some mistakes in HWE test which strongly affects included studies and the final conclusion. Here we aim to comment on the issue.
尹等人。（2019 年），BSR20180923）最近发表了一项关于 K469E（rs5498）多态性与冠心病（CHD）风险之间关联的荟萃分析。作者根据纳入标准纳入了 14 项研究。他们指出，只有其基因分型数据符合 Hardy-Weinberg 平衡（HWE）的研究才被纳入荟萃分析。他们还对这些研究进行了 HWE 检验，发现所有对照组均符合 HWE。作为他们的主要发现，他们得出结论，“K469E 多态性与 CHD 风险相关，K 等位基因是中国和高加索人群中发生 CHD 的更重要的危险因素”。然而，HWE 检验似乎存在一些错误，这些错误强烈影响了纳入的研究和最终结论。在这里，我们旨在对这个问题进行评论。
