Arushanian E B, Beĭer E V
Biull Eksp Biol Med. 1992 Oct;114(10):372-4.
After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression. The drug attenuated depressogenic properties of reserpine and clonidine. Propranolol antidepressive activity is attributed to blockade cerebral adrenoreceptors.
给大鼠长期服用普萘洛尔(1和5毫克/千克,14天)后,强迫游泳的时间进程随抑郁节律指数的降低而改变。该药物减弱了利血平和可乐定的致抑郁特性。普萘洛尔的抗抑郁活性归因于对脑内肾上腺素能受体的阻断。