针刺足少阳胆经阳陵泉穴对四氯化碳诱导的大鼠慢性肝损伤的保肝作用
Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl4-induced chronic liver damage in rats.
作者信息
Yim Yun-Kyoung, Lee Hyun, Hong Kwon-Eui, Kim Young-Il, Lee Byung-Ryul, Kim Tae-Han, Yi Ji-Young
机构信息
Department of Meridian abd Acupoint, College of Oriental Medicine, Daejeon University, #12407, 96-3, Dong-gu, Daejeon 300-716, South Korea.
出版信息
World J Gastroenterol. 2006 Apr 14;12(14):2245-9. doi: 10.3748/wjg.v12.i14.2245.
AIM
To investigate the hepatoprotective effect of manual acupuncture at Yanglingquan (GB34) on CCl4-induced chronic liver damage in rats.
METHODS
Rats were injected intraperitoneally with CCl4 (1 mL/kg) and treated with manual acupuncture using reinforcing manipulation techniques at left GB34 (Yanglingquan) 3 times a week for 10 wk. A non-acupoint in left gluteal area was selected as a sham point. To estimate the hepatoprotective effect of manual acupuncture at GB34, measurement of liver index, biochemical assays including serum ALT, AST, ALP and total cholesterol, histological analysis and blood cell counts were conducted.
RESULTS
Manual acupuncture at GB34 reduced the liver index, serum ALT, AST, ALP and total cholesterol levels as compared with the control group and the sham acupuncture group. It also increased and normalized the populations of WBC and lymphocytes.
CONCLUSION
Manual acupuncture with reinforcing manipulation techniques at left GB34 reduces liver toxicity, protects liver function and liver tissue, and normalizes immune activity in CCl4-intoxicated rats.
目的
探讨针刺阳陵泉（GB34）对四氯化碳诱导的大鼠慢性肝损伤的保肝作用。
方法
大鼠腹腔注射四氯化碳（1 mL/kg），并采用补法手法针刺左侧GB34（阳陵泉），每周3次，共10周。选取左侧臀区的一个非穴位作为假穴。为评估针刺GB34的保肝作用，进行了肝脏指数测量、包括血清ALT、AST、ALP和总胆固醇在内的生化检测、组织学分析和血细胞计数。
结果
与对照组和假针刺组相比，针刺GB34降低了肝脏指数、血清ALT、AST、ALP和总胆固醇水平。它还增加并使白细胞和淋巴细胞数量恢复正常。
结论
采用补法手法针刺左侧GB34可降低四氯化碳中毒大鼠的肝毒性，保护肝功能和肝组织，并使免疫活性恢复正常。
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