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Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study.巴巴多斯哮喘遗传学研究中CD14 / -260多态性与室内灰尘内毒素暴露的评估。
J Allergy Clin Immunol. 2005 Jun;115(6):1203-9. doi: 10.1016/j.jaci.2005.03.001.
2
CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma.CD14烟草基因-环境相互作用改变拉丁裔哮喘患者的哮喘严重程度和免疫球蛋白E水平。
Am J Respir Crit Care Med. 2005 Jul 15;172(2):173-82. doi: 10.1164/rccm.200409-1232OC. Epub 2005 May 5.
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Polymorphisms of genes involved in innate immunity: association with preterm delivery.先天性免疫相关基因的多态性：与早产的关联。
Mol Hum Reprod. 2004 Dec;10(12):911-5. doi: 10.1093/molehr/gah120. Epub 2004 Oct 29.
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Neonatal cerebral white matter injury in preterm infants is associated with culture positive infections and only rarely with metabolic acidosis.
Am J Obstet Gynecol. 2004 Oct;191(4):1305-10. doi: 10.1016/j.ajog.2004.06.058.
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Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases?白细胞介素-6对炎症反应的遗传易感性：对多种主要疾病有何影响？
Clin Chem. 2004 Nov;50(11):2136-40. doi: 10.1373/clinchem.2004.037531. Epub 2004 Sep 13.
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Tumor necrosis factor alpha -- 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants.
Pediatr Infect Dis J. 2004 May;23(5):424-8. doi: 10.1097/01.inf.0000122607.73324.20.
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Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen.
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Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used.白细胞介素-10基因启动子中的基因变异镶嵌体根据所使用的刺激方式影响白细胞介素-10的产生。
Genes Immun. 2004 Jun;5(4):246-55. doi: 10.1038/sj.gene.6364073.
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Interleukin 10-2849AA genotype protects against pre-eclampsia.白细胞介素10 - 2849AA基因型可预防子痫前期。
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Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations.多胎妊娠中白细胞介素-4和-10基因多态性与自发性早产
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极低出生体重儿机械通气时白细胞介素-10、白细胞介素-6和CD14基因多态性与脓毒症转归

IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants.

作者信息

Baier R John, Loggins John, Yanamandra Krishna

机构信息

Department of Pediatrics, University of Manitoba, WR 116 735 Notre Dame Avenue Winnipeg, Manitoba, R3E 0L8, Canada.

出版信息

BMC Med. 2006 Apr 12;4:10. doi: 10.1186/1741-7015-4-10.

DOI:10.1186/1741-7015-4-10
PMID:16611358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1513390/
Abstract

BACKGROUND

Genetic variation in the innate immune system of the host may play a role in determining the risk of developing infection, as well as outcome from infection.

METHODS

Infectious complications were retrospectively determined in 293 (233 African-American (AA), 57 Caucasian and 3 Hispanic) mechanically ventilated very low birth weight (VLBW) infants (<1500 grams at birth) who were genotyped for the IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T single nucleotide polymorphisms (SNPs).

RESULTS

The IL-6 -174C allele was associated with an increased incidence of late blood stream infection (BSI) in AA but not Caucasian infants. In AA infants with the C allele the incidence of late BSI was 20/29 (69%) compared to 94/204 (46%) in homozygous GG infants (RR 2.6, 95% CI: 1.1-6.0, p = 0.021). The IL-10 -1082A allele was associated with an increased incidence of late BSI. One or more episodes of late BSI developed in 14 (35%) of 40 infants with the GG genotype, 71 (49%) of 145 infants with the GA genotype and 63 (58%) of 108 infants with the AA genotype (p = 0.036). Infants with the A allele (AA or GA genotypes) had an incidence of late BSI that was 134/253 (53%) compared to 14/40 (35%) in homozygous GG infants (RR 2.1, 95% CI: 1.04-4.19, p = 0.035). The CD14 -260 C/T SNP did not alter the overall risk for BSI in ventilated VLBW infants. Multiple BSI episodes were more common in the TT genotype group (CC: 17%, CT: 11%, TT: 30%, p = 0.022). This effect was due to the strong effect of the TT genotype on the incidence of multiple BSI in AA infants (CC: 15%, CT: 11%, TT: 39%, p = 0.003).

CONCLUSION

The IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T SNPs may alter risk for BSI in ventilated VLBW infants.

摘要

背景

宿主先天免疫系统的基因变异可能在决定感染风险以及感染结局方面发挥作用。

方法

对293例机械通气的极低出生体重（VLBW）婴儿（出生时体重<1500克）进行回顾性研究，确定其感染并发症情况。这些婴儿接受了白细胞介素-6（IL-6）-174 G/C、白细胞介素-10（IL-10）-1082 G/A和CD14 -260 C/T单核苷酸多态性（SNP）基因分型，其中非裔美国人（AA）233例、白种人57例、西班牙裔3例。

结果

IL-6 -174C等位基因与AA婴儿而非白种人婴儿晚期血流感染（BSI）发生率增加相关。携带C等位基因的AA婴儿晚期BSI发生率为20/29（69%），而纯合GG婴儿为94/204（46%）（相对风险2.6，95%置信区间：1.1 - 6.0，p = 0.021）。IL-10 -1082A等位基因与晚期BSI发生率增加相关。40例GG基因型婴儿中有14例（35%）发生1次或多次晚期BSI，145例GA基因型婴儿中有71例（49%），108例AA基因型婴儿中有63例（58%）（p = 0.036）。携带A等位基因（AA或GA基因型）的婴儿晚期BSI发生率为134/253（53%），而纯合GG婴儿为14/40（35%）（相对风险2.1，95%置信区间：1.04 - 4.19，p = 0.035）。CD14 -260 C/T SNP未改变机械通气VLBW婴儿发生BSI的总体风险。多次BSI发作在TT基因型组中更常见（CC：17%，CT：11%，TT：30%，p = 0.022）。这种效应是由于TT基因型对AA婴儿多次BSI发生率的强烈影响（CC：15%，CT：11%，TT：39%，p = 0.003）。

结论

IL-6 -174 G/C、IL-10 -1082 G/A和CD14 -260 C/T SNPs可能改变机械通气VLBW婴儿发生BSI的风险。