Department of Traumatology, Tiantai People's Hospital, PR China.
Intensive Care Unit, Tiantai People's Hospital, PR China.
Innate Immun. 2019 Nov;25(8):465-472. doi: 10.1177/1753425919872818. Epub 2019 Aug 31.
The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were included in this meta-analysis. There was no significant association between the IL-6-174G/C polymorphism and sepsis risk in the total population (C vs. G: OR = 1.04, 95% CI = 0.79–1.38; CC vs. GG: OR = 0.86, 95% CI = 0.53–1.41; CG vs. GG: OR = 0.99, 95% CI = 0.79–1.24; dominant model: OR = 0.97, 95% CI = 0.74–1.29; recessive model: OR = 0.92, 95% CI = 0.61–1.39). When patients were stratified according to ethnicity, a statistically significant association was observed in Asians and Africans. As for the -572G/C polymorphism, the results showed that the IL-6-572C/G polymorphism was not associated with sepsis susceptibility (G vs. C: OR = 0.98, 95% CI = 0.79–1.22; GG vs. CC: OR = 1.46, 95% CI = 0.53–4.03; GC vs. CC: OR = 0.82, 95% CI = 0.54–1.27; dominant model: OR = 0.88, 95% CI = 0.55–1.41; recessive model: OR = 1.55, 95% CI = 0.82–2.92). The data indicated that the IL-6-174G/C polymorphism may contribute to sepsis risk, especially in Africans and Asians. No significant association was observed between the IL-6-572G/C polymorphism and sepsis risk.
本研究旨在探讨白细胞介素-6（IL-6）多态性是否与脓毒症相关。根据纳入标准，在数据库中搜索 IL-6 多态性与脓毒症的相关性，并使用综合荟萃分析软件进行分析。本荟萃分析共纳入 16 项研究。在总体人群中，IL-6-174G/C 多态性与脓毒症风险之间无显著相关性（C 对 G：OR=1.04，95%CI=0.79-1.38；CC 对 GG：OR=0.86，95%CI=0.53-1.41；CG 对 GG：OR=0.99，95%CI=0.79-1.24；显性模型：OR=0.97，95%CI=0.74-1.29；隐性模型：OR=0.92，95%CI=0.61-1.39）。根据种族分层后，在亚洲人和非洲人中观察到具有统计学意义的相关性。至于-572G/C 多态性，结果表明 IL-6-572C/G 多态性与脓毒症易感性无关（G 对 C：OR=0.98，95%CI=0.79-1.22；GG 对 CC：OR=1.46，95%CI=0.53-4.03；GC 对 CC：OR=0.82，95%CI=0.54-1.27；显性模型：OR=0.88，95%CI=0.55-1.41；隐性模型：OR=1.55，95%CI=0.82-2.92）。数据表明，IL-6-174G/C 多态性可能导致脓毒症风险增加，尤其是在非洲人和亚洲人中。IL-6-572G/C 多态性与脓毒症风险之间无显著相关性。
