Maier Wolfgang, Zobel Astrid, Wagner Michael
Department of Psychiatry, University of Bonn, Bonn, Germany.
Curr Opin Psychiatry. 2006 Mar;19(2):165-70. doi: 10.1097/01.yco.0000214342.52249.82.
Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged.
Evidence for basic neurobiological processes common for both disorders is expanding with regard to (a) susceptibility genes, (b) neurodevelopment (for example myelination), and (c) brain functions (for example sensory gating, visuospatial achievement). Recent epidemiological studies also stress communalities.
The diagnostic split between schizophrenia and bipolar disorder is unable to define distinct etiological and/or pathophysiological entities.
随着近期主要在遗传学和神经生物学领域取得的进展，精神分裂症和双相情感障碍之间诊断区分的有效性正受到越来越多的挑战。
关于以下方面，这两种疾病共有的基本神经生物学过程的证据正在不断增加：（a）易感基因；（b）神经发育（例如髓鞘形成）；以及（c）脑功能（例如感觉门控、视觉空间能力）。近期的流行病学研究也强调了两者的共性。
精神分裂症和双相情感障碍之间的诊断划分无法界定不同的病因学和/或病理生理学实体。
