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锁骨骨髓炎:头颈癌手术后的一种罕见并发症。

Clavicular osteomyelitis: a rare complication after surgery for head and neck cancer.

作者信息

Piazza Cesare, Magnoni Laura, Nicolai Piero

机构信息

Department of Otolaryngology, University of Brescia, Spedali Civili, Piazza Spedali Civili 1, 25123, Brescia, Italy.

出版信息

Eur Arch Otorhinolaryngol. 2006 Jul;263(7):653-6. doi: 10.1007/s00405-006-0040-z. Epub 2006 Apr 13.

Abstract

Clavicular osteomyelitis (COM) is a rarely described disease entity, occurring especially after head and neck surgery. We herein report the ninth case according to the English language literature and describe the pertinent diagnostic and therapeutic measures to treat this complication. A 63-year-old Caucasian male underwent total laryngectomy and partial pharyngectomy for a post-radiotherapy recurrence of a T2 hypopharyngeal cancer. He presented multiple systemic (cardiovascular problems, previous pneumonectomy, malnutrition) and local-regional (previous radiotherapy, neck dissection, tracheostomy) factors favoring postoperative complications. Sixteen days after surgery, he developed a painful swelling with overlying erythematous skin at the level of the medial portion of the left clavicle. A purulent discharge from the adjacent stomal dehiscence was also noted. COM, suspected on the base of patient's history and clavicular inspection, was confirmed by CT scan. Surgical debridement allowed for definitive diagnosis, ruling out any possible suspicion of stomal recurrence or secondary localization to the clavicle. Cultures from the debrided bone sequestra grew Streptococcus pyogenes Group A and allowed for proper targeting of antibiotic therapy, which was carried out for 4 weeks after surgery. Four years after surgery the patient is tumor-free and does not show any sequela related to the COM or its treatment. COM is a rarely encountered complication after major head and neck surgery. Nevertheless, prompt diagnosis and treatment are mandatory due to the potential life-threatening evolution of this condition.

摘要

锁骨骨髓炎(COM)是一种鲜有描述的疾病实体,尤其在头颈部手术后发生。我们在此报告根据英文文献的第九例病例,并描述治疗该并发症的相关诊断和治疗措施。一名63岁的白种男性因T2下咽癌放疗后复发接受了全喉切除术和部分咽切除术。他存在多种全身(心血管问题、既往肺切除术、营养不良)和局部区域(既往放疗、颈部清扫术、气管切开术)因素,易导致术后并发症。术后16天,他在左锁骨内侧部分出现疼痛性肿胀,皮肤伴有红斑。还注意到相邻造口裂开处有脓性分泌物。根据患者病史和锁骨检查怀疑为COM,CT扫描得以确诊。手术清创实现了明确诊断,排除了对造口复发或锁骨继发性定位的任何可能怀疑。清创后的骨死骨培养出A组化脓性链球菌,从而确定了抗生素治疗的正确靶点,术后进行了4周的抗生素治疗。术后四年,患者无肿瘤,未出现与COM或其治疗相关的任何后遗症。COM是大型头颈部手术后罕见的并发症。然而,由于该疾病可能危及生命的发展过程,必须及时诊断和治疗。

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