Rocca M A, Ceccarelli A, Falini A, Tortorella P, Colombo B, Pagani E, Comi G, Scotti G, Filippi M
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy.
J Neurol Neurosurg Psychiatry. 2006 May;77(5):686-9. doi: 10.1136/jnnp.2005.080002.
Diffusion tensor (DT) magnetic resonance imaging (MRI) has the potential to disclose subtle abnormalities in the brain of migraine patients. This ability may be increased by the use of high field magnets. A DT MRI on a 3.0 tesla scanner was used to measure the extent of tissue damage of the brain normal appearing white (NAWM) and grey matter in migraine patients with T2 visible abnormalities.
Dual echo, T1 weighted and DT MRI with diffusion gradients applied in 32 non-collinear directions were acquired from 16 patients with migraine and 15 sex and age matched controls. Lesion load on T2 weighted images was measured using a local thresholding segmentation technique, and brain atrophy assessed on T1 weighted images using SIENAx. Mean diffusivity and fractional anisotropy histograms of the NAWM and mean diffusivity histograms of the grey matter were also derived.
Brain atrophy did not differ between controls and patients. Compared with healthy subjects, migraine patients had significantly reduced mean diffusivity histogram peak height of the grey matter (p=0.04). No diffusion changes were detected in patients' NAWM. In migraine patients, no correlation was found between T2 weighted lesion load and brain DT histogram derived metrics, whereas age was significantly correlated with grey matter mean diffusivity histogram peak height (p=0.05, r=-0.52).
DT MRI at high field strength discloses subtle grey matter damage in migraine patients, which might be associated with cognitive changes in these patients.
扩散张量（DT）磁共振成像（MRI）有潜力揭示偏头痛患者大脑中的细微异常。使用高场强磁体可能会增强这种能力。本研究采用3.0特斯拉扫描仪进行DT MRI，以测量T2可见异常的偏头痛患者脑内正常表现白质（NAWM）和灰质的组织损伤程度。
对16例偏头痛患者和15例年龄、性别匹配的对照者进行双回波、T1加权及在32个非共线方向施加扩散梯度的DT MRI检查。使用局部阈值分割技术测量T2加权图像上的病灶负荷，并使用SIENAx在T1加权图像上评估脑萎缩情况。还得出了NAWM的平均扩散率和分数各向异性直方图以及灰质的平均扩散率直方图。
对照组和患者之间脑萎缩情况无差异。与健康受试者相比，偏头痛患者灰质的平均扩散率直方图峰值高度显著降低（p = 0.04）。在患者的NAWM中未检测到扩散变化。在偏头痛患者中，未发现T2加权病灶负荷与脑DT直方图衍生指标之间存在相关性，而年龄与灰质平均扩散率直方图峰值高度显著相关（p = 0.05，r = -0.52）。
高场强DT MRI揭示了偏头痛患者脑内细微的灰质损伤，这可能与这些患者的认知变化有关。
