Shin Jae Il, Park Jee Min, Lee Jae Seung, Kim Ji Hong, Kim Pyung Kil, Jeong Hyeon Joo
Department of Paediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Ku, 120-752 , C.P.O. Box 8044, Seoul, Korea.
Clin Rheumatol. 2006 Sep;25(5):759-60. doi: 10.1007/s10067-005-0066-4. Epub 2006 Apr 14.
Schönlein-Henoch nephritis (SHN) usually presents with micro-haematuria or mild proteinuria but can be associated with heavy proteinuria and nephrotic or acute nephritic syndrome. Although the treatment of SHN is still under debate, it has been suggested that cyclosporin A (CsA) may be beneficial in children with severe SHN, as reported by Ronkainen et al. (Pediatr Nephrol 18:1138-1142, 2003) and Someya et al. (Pediatr Int 46:111-113, 2004). However, histological effects of CsA on severe SHN had not been evaluated in their evaluations. We report the successful use of CsA in a male patient with severe SHN with nephrotic-range proteinuria, who failed to respond to methylprednisolone pulse and azathioprine therapy.
过敏性紫癜性肾炎（SHN）通常表现为镜下血尿或轻度蛋白尿，但也可能伴有大量蛋白尿以及肾病综合征或急性肾炎综合征。尽管SHN的治疗仍存在争议，但正如Ronkainen等人（《小儿肾脏病学》18:1138 - 1142, 2003）和Someya等人（《儿科学国际》46:111 - 113, 2004）所报道的，有人提出环孢素A（CsA）可能对重症SHN患儿有益。然而，他们的评估中未对CsA对重症SHN的组织学影响进行评估。我们报告了CsA成功用于一名患有重症SHN且蛋白尿达到肾病范围、对甲泼尼龙冲击治疗和硫唑嘌呤治疗无反应的男性患者的案例。
