Roch-Arveiller M, Fontagne J, el Abbouyi A, Raichvarg D, Giroud J P
CNRS URA 595-Pharmacologie and Biochimie A Hôpital Cochin, Paris, France.
Inflammation. 1991 Dec;15(6):437-45. doi: 10.1007/BF00923341.
An impairment of polymorphonuclear leukocyte (PMN) functions has been described following burn trauma. It was thus of interest to investigate the effect of RU 41740, an agent known to stimulate these cells, on rat PMN functions after burn injury. In the present study the responsiveness to classical stimuli of PMN from untreated burned rats was approximately 40% lower than healthy control values. In vitro treatment with RU 41740 increased oxidative metabolism of PMNs from burned and healthy rats. The effect was dose-related but was most striking in the case of PMNs from healthy rats. Significant differences were obtained with concentrations higher than 1 micrograms/ml for healthy rats but only 10 micrograms/ml for burned rats. In vivo treatment with RU 41740 also led to an enhancement of PMN oxidative metabolism on both burned and healthy rats. The maximal effective dose was 10 mg/kg/day in both cases. In contrast, 25 and 50 mg/kg/day doses inhibited PMN oxidative metabolism.
烧伤创伤后已发现多形核白细胞（PMN）功能受损。因此，研究已知能刺激这些细胞的RU 41740对烧伤后大鼠PMN功能的影响具有重要意义。在本研究中，未治疗的烧伤大鼠的PMN对经典刺激的反应性比健康对照值低约40%。用RU 41740进行体外处理可增加烧伤和健康大鼠PMN的氧化代谢。这种作用呈剂量相关性，但在健康大鼠的PMN中最为显著。健康大鼠浓度高于1微克/毫升时出现显著差异，而烧伤大鼠仅在10微克/毫升时出现显著差异。用RU 41740进行体内处理也可增强烧伤和健康大鼠的PMN氧化代谢。两种情况下的最大有效剂量均为10毫克/千克/天。相比之下，25毫克/千克/天和50毫克/千克/天的剂量会抑制PMN氧化代谢。
