仔细观察完全水合的流体相二棕榈酰磷脂酰胆碱双层膜的结构。
Closer look at structure of fully hydrated fluid phase DPPC bilayers.
作者信息
Kucerka Norbert, Tristram-Nagle Stephanie, Nagle John F
机构信息
Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
出版信息
Biophys J. 2006 Jun 1;90(11):L83-5. doi: 10.1529/biophysj.106.086017. Epub 2006 Apr 14.
Abstract
X-ray data are presented for the benchmark dipalmitoylphosphatidylcholine lipid bilayer in the most biologically relevant state in which the bilayers are fully hydrated and in the fluid (liquid-crystalline) phase. Form factors F(q(z)) are obtained from a combination of two sample preparations, oriented stacks of bilayers for q(z) extending to 0.85 A(-1) and unilamellar vesicles for smaller q(z). Modeling obtains the electron density profile and values for the area per molecule, for the locations of the component groups, and for the different types of thicknesses of the bilayer, such as the hydrocarbon thickness and the steric thickness.
摘要
本文给出了基准二棕榈酰磷脂酰胆碱脂质双层在最具生物学相关性状态下的X射线数据，即双层完全水合且处于流体（液晶）相的状态。通过两种样品制备方法的结合获得了形状因子F(q(z))，对于q(z)延伸至0.85 Å⁻¹的情况采用双层的定向堆叠，对于较小的q(z)则采用单层囊泡。通过建模得到了电子密度分布、每个分子的面积值、各组成基团的位置以及双层不同类型的厚度值，如烃链厚度和空间厚度。
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