Vincent Jean-Louis, Piagnerelli Michael
Department of Intensive Care Medicine, Erasme Hospital, Free University of Brussels, Belgium.
Crit Care Med. 2006 May;34(5 Suppl):S96-101. doi: 10.1097/01.CCM.0000214314.57109.CD.
To summarize the incidences of anemia and blood transfusions in critically ill patients, assess their comparative risks and benefits, and briefly speculate on the possible effects of leukoreduction and blood storage on the need to reevaluate transfusion triggers.
A review of the current literature was performed.
Anemia is common in intensive care unit patients and is associated with increased mortality. Some 20-53% of intensive care unit patients will receive a blood transfusion during their stay, and these have also been associated with worse outcomes. Leukoreduction may limit some of the infectious and immunomodulatory risks associated with blood transfusion.
Data on the risks and benefits of blood transfusion are conflicting, and with recent changes in blood transfusion practice, including the widespread introduction of leukoreduction, it is time to reevaluate our transfusion triggers.
总结重症患者贫血和输血的发生率，评估其相对风险和益处，并简要推测白细胞滤除和血液储存对重新评估输血触发因素必要性的可能影响。
对当前文献进行综述。
贫血在重症监护病房患者中很常见，且与死亡率增加相关。约20% - 53%的重症监护病房患者在住院期间会接受输血，而输血也与更差的预后相关。白细胞滤除可能会限制一些与输血相关的感染和免疫调节风险。
关于输血风险和益处的数据相互矛盾，并且随着近期输血实践的变化，包括白细胞滤除的广泛应用，是时候重新评估我们的输血触发因素了。
