Johansson Leif, Oberg Dan, Melén Ingemar, Bende Mats
Department of Otorhinolaryngology, Central Hospital, Skövde, Sweden.
Acta Otolaryngol. 2006 Mar;126(3):288-90. doi: 10.1080/00016480500388877.
The hypothesis that decongestants reduce the size of nasal polyps could not be verified. Decongestion is therefore recommended prior to nasal endoscopy, especially in polyp diagnosis, as it does not artificially change the size of the polyps.
The role of nasal decongestants in nasal stuffiness is well established and their action is well known. Decongestants are also used prior to nasal endoscopy to achieve a better view of the nasal cavity in order to diagnose polyps. The question is whether this decongestion invalidates the estimation of polyp size in clinical and scientific practice. The aim of this study was to evaluate possible effects of topical decongestants on polyp extension in patients with nasal polyposis.
The effect of the decongestants nafazoline and epinephrine on nasal polyp size was assessed by means of a double-blind, placebo-controlled randomized study. A sensitive endoscopic scoring system, lateral imaging, was used to assess the size and extension of the nasal polyps.
No significant effect of decongestion on polyp size could be found for either treatment.
减充血剂可减小鼻息肉大小这一假设未得到证实。因此，建议在鼻内镜检查前进行减充血，尤其是在息肉诊断时，因为它不会人为改变息肉大小。
鼻减充血剂在鼻阻塞方面的作用已得到充分证实，其作用机制也广为人知。鼻内镜检查前也会使用减充血剂，以便更好地观察鼻腔以诊断息肉。问题在于这种减充血在临床和科学实践中是否会使息肉大小的估计无效。本研究的目的是评估局部减充血剂对鼻息肉病患者息肉大小的可能影响。
通过双盲、安慰剂对照随机研究评估减充血剂萘甲唑啉和肾上腺素对鼻息肉大小的影响。使用一种敏感的内镜评分系统——侧位成像来评估鼻息肉的大小和范围。
两种治疗方法均未发现减充血对息肉大小有显著影响。
