Stava Charles, Beck Martha, Weiss L Todd, Lopez Adriana, Vassilopoulou-Sellin Rena
Department of Endocrine Neoplasia and Hormonal Disorders, Unit 435, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
BMC Cancer. 2006 Apr 18;6:95. doi: 10.1186/1471-2407-6-95.
The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors.
A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial responses were analyzed and compared with those of the survivors from other cancers.
The melanoma survivors were 44.8 +/- 12.8 years of age at diagnosis (significantly younger than the survivors of other cancers) and 63.7 +/- 12.8 years at survey. Melanoma survivors were less likely to report that cancer had affected their health than survivors of other cancers (15.8% vs. 34.9%). The 577 individuals treated with surgery alone reported arthritis/osteoporosis, cataracts, and heart problems most frequently (less often than survivors of other cancers). The 391 individuals who had undergone combined treatments reported circulation problems and kidney problems generally as often as survivors of other cancers. Health problems were not associated with number of decades since diagnosis but with age at diagnosis, treatment modality, and family relationships.
We present information from a large cohort of long-term survivors of melanoma. As a group, they were less likely to report that cancer had affected their overall health than survivors of other cancers; a number of disease related and psychosocial factors appear to influence their health profiles.
黑色素瘤的发病率和生存率正在上升，但对于成年幸存者的长期健康影响却知之甚少。
对996名黑色素瘤幸存者（577名单独接受手术治疗，391名接受联合治疗）进行了健康调查。分析了他们的医学/生理和社会心理反应，并与其他癌症幸存者的反应进行了比较。
黑色素瘤幸存者确诊时的年龄为44.8±12.8岁（显著低于其他癌症幸存者），调查时为63.7±12.8岁。与其他癌症幸存者相比，黑色素瘤幸存者较少报告癌症对其健康产生影响（15.8%对34.9%）。577名单独接受手术治疗的个体最常报告患有关节炎/骨质疏松症、白内障和心脏问题（比其他癌症幸存者报告的频率低）。391名接受联合治疗的个体报告循环系统问题和肾脏问题的频率与其他癌症幸存者总体相当。健康问题与确诊后的年数无关，而是与确诊年龄、治疗方式和家庭关系有关。
我们提供了来自一大群黑色素瘤长期幸存者的信息。作为一个群体，他们比其他癌症幸存者更少报告癌症对其整体健康产生影响；一些与疾病相关和社会心理因素似乎影响着他们的健康状况。
