Pene Frédéric, Merlat Annabelle, Vabret Astrid, Rozenberg Flore, Buzyn Agnès, Dreyfus François, Cariou Alain, Freymuth François, Lebon Pierre
Medical Intensive Care Unit, Cochin-Saint Vincent de Paul Hospital, University Paris V, Paris, France.
Clin Infect Dis. 2003 Oct 1;37(7):929-32. doi: 10.1086/377612. Epub 2003 Sep 8.
Coronaviruses strains 229E and OC43 have been associated with various respiratory illnesses ranging from the self-resolving common cold to severe pneumonia. Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available. Here we report 2 well-documented cases of pneumonia related to coronavirus 229E, each with a different clinical presentation. Diagnosis was made on the basis of viral culture and electron microscopy findings that exhibited typical crown-like particles and through amplification of the viral genome by reverse transcriptase-polymerase chain reaction. On the basis of this report, coronaviruses should be considered as potential causative microorganisms of pneumonia in immunocompromised patients.
冠状病毒株229E和OC43与从自限性普通感冒到严重肺炎等各种呼吸道疾病有关。虽然慢性基础疾病是严重呼吸道病毒感染的主要决定因素，但关于免疫功能低下患者中冠状病毒相关肺炎的数据却很少。在此，我们报告2例记录充分的与冠状病毒229E相关的肺炎病例，每例都有不同的临床表现。诊断是基于病毒培养和电子显微镜检查结果，这些结果显示出典型的冠状颗粒，并通过逆转录-聚合酶链反应扩增病毒基因组而做出的。基于本报告，冠状病毒应被视为免疫功能低下患者肺炎的潜在致病微生物。
