Grebel Janel E, Young Connie C, Suffet I H Mel
Environmental Science and Engineering Program, UCLA, School of Public Health, Charles E. Young Drive South, Box 951772, Los Angeles, CA 90095, USA.
J Chromatogr A. 2006 Jun 2;1117(1):11-8. doi: 10.1016/j.chroma.2006.03.044. Epub 2006 Apr 18.
A method was developed for the extraction of seven N-nitrosamine compounds from water by solid-phase microextraction (SPME). The method developed requires a total analysis time of only 1.25 h for both extraction and detection (versus 3-20 h for other isolation techniques). Three gas chromatography (GC) detection systems were tested with the SPME method, nitrogen chemiluminesence detection (NCD), nitrogen-phosphorus detection (NPD) and chemical ionization mass spectrometry (CI-MS), with method detection limits (MDLs) found in the ng/L range. This method was used to analyze wastewater samples and showed excellent selectivity of extraction. The detection limits of this method for N-nitrosodimethylamine (NDMA) range from 30 to 890 ng/L as a function of detector type. The excellent selectivity of SPME in addition to the fast analysis time would make this method ideal for general surveys, wastewater analysis and laboratory studies (e.g. degradation kinetics or formation potential).
开发了一种通过固相微萃取（SPME）从水中提取七种N-亚硝胺化合物的方法。所开发的方法对于提取和检测而言，总共只需1.25小时的分析时间（相比之下，其他分离技术需要3至20小时）。用SPME方法测试了三种气相色谱（GC）检测系统，即氮化学发光检测（NCD）、氮磷检测（NPD）和化学电离质谱（CI-MS），方法检测限（MDL）在纳克/升范围内。该方法用于分析废水样品，显示出优异的萃取选择性。该方法对N-亚硝基二甲胺（NDMA）的检测限根据检测器类型在30至890纳克/升范围内变化。除了分析时间短之外，SPME的优异选择性使该方法成为一般调查、废水分析和实验室研究（如降解动力学或生成潜力）的理想选择。
