McCabe Sean Esteban, Cranford James A, Boyd Carol J
Substance Abuse Research Center, The University of Michigan, Ann Arbor, MI 48105-2194, USA.
Drug Alcohol Depend. 2006 Oct 1;84(3):281-8. doi: 10.1016/j.drugalcdep.2006.03.006. Epub 2006 Apr 18.
This study examined the relationship between past-year drinking behaviors and nonmedical use of prescription drugs (NMUPD) in a nationally representative sample. Prevalence estimates in the United States were derived based on data collected from face-to-face interviews using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n=43,093 individuals aged 18 years and older). Nonmedical use of prescription opioids, stimulants, tranquilizers, and sedatives was more prevalent among individuals with alcohol use disorders (AUDs) than those without AUDs. The odds of reporting NMUPD were 18 times higher among alcohol dependent participants compared to past-year abstainers (OR=18.2, 95% CI=13.9-23.8). Although individuals with AUDs constituted less than 9% of the total sample, those with AUDs accounted for more than one in every three nonmedical users of prescription drugs. The past-year co-occurrence of AUDs and NMUPD was more prevalent among young adults 18-24 years of age than individuals 25 years and older. More than one in every four young adults aged 18-24 years who met the criteria for past-year DSM-IV alcohol dependence also reported past-year NMUPD. These findings suggest that the treatment for AUDs should include a thorough assessment of NMUPD, especially among young adults.
本研究在一个具有全国代表性的样本中,考察了过去一年饮酒行为与非医疗目的使用处方药(NMUPD)之间的关系。美国的患病率估计值是基于使用《国家酒精及相关状况流行病学调查》(NESARC)通过面对面访谈收集的数据得出的(样本为43,093名18岁及以上的个体)。与无酒精使用障碍(AUD)的个体相比,非医疗目的使用处方阿片类药物、兴奋剂、镇静剂和安眠药在患有AUD的个体中更为普遍。与过去一年戒酒者相比,酒精依赖参与者报告NMUPD的几率高出18倍(比值比=18.2,95%置信区间=13.9-23.8)。尽管患有AUD的个体占总样本的比例不到9%,但每三个非医疗目的使用处方药的人中就有一个以上患有AUD。过去一年中,AUD和NMUPD共现的情况在18-24岁的年轻人中比25岁及以上的个体更为普遍。在符合过去一年《精神疾病诊断与统计手册》第四版(DSM-IV)酒精依赖标准的18-24岁年轻人中,超过四分之一的人还报告了过去一年的NMUPD。这些发现表明,对AUD的治疗应包括对NMUPD进行全面评估,尤其是在年轻人中。