表达妊娠特异性变异表面抗原的恶性疟原虫寄生虫与绒毛膜癌细胞系BeWo强烈黏附。
Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo.
作者信息
Haase Rikke N, Megnekou Rosette, Lundquist Maja, Ofori Michael F, Hviid Lars, Staalsoe Trine
机构信息
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Denmark.
出版信息
Infect Immun. 2006 May;74(5):3035-8. doi: 10.1128/IAI.74.5.3035-3038.2006.
Abstract
Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA(PAM)). We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro.
摘要
导致妊娠相关疟疾的胎盘隐匿型恶性疟原虫寄生虫表达妊娠特异性变异表面抗原（VSA(PAM)）。我们在此报告，表达VSA(PAM)的患者分离株与绒毛膜癌细胞系BeWo强烈黏附，并且BeWo细胞系可用于在体外有效筛选VSA(PAM)的表达。
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