Moresco Rafael Noal, Júnior Ronald Halla, Cláudio Rosa Vargas Luis, Mariano da Rocha Silla Lúcia
Department of Hematology and Bone Marrow Transplantation, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
J Thromb Thrombolysis. 2006 Apr;21(2):199-202. doi: 10.1007/s11239-006-4837-9.
D-dimer and fibrinogen/fibrin degradation products (FDP) levels are elevated in subjects with thromboembolic disorders, and the assays for detection of D-dimer and FDP are used in many laboratories for the investigation of these disorders. The aim of this study was to evaluate the association between the plasma levels of D-dimer and FDP in the investigation of thromboembolic disorders.
D-dimer and FDP immunoassays were performed in 217 consecutive blood samples from subjects with suspected of thromboembolic disorders by use of Liatest D-dimer and Plasma FDP.
FDP results were classified in: <5, 5-20, >20 microg/mL, and D-dimer levels obtained in these groups ranged to 350-1,210 ng/mL, 420-1,960 ng/mL, and 1,190-51,170 ng/mL, respectively. A significant association between D-dimer levels and the reaction times necessary to occur agglutination in latex agglutination test for FDP was observed.
There was an association between plasma levels of D-dimer and FDP. The preliminary determination of FDP levels could be useful because it allows estimating the D-dimer levels before of the automated systems analysis, reducing costs associated to dilutions of plasma samples.
在血栓栓塞性疾病患者中，D - 二聚体和纤维蛋白原/纤维蛋白降解产物（FDP）水平会升高，许多实验室使用检测D - 二聚体和FDP的检测方法来研究这些疾病。本研究的目的是评估在血栓栓塞性疾病研究中D - 二聚体和FDP血浆水平之间的关联。
通过使用Liatest D - 二聚体和血浆FDP检测试剂盒，对217例疑似血栓栓塞性疾病患者的连续血样进行D - 二聚体和FDP免疫测定。
FDP结果分为：<5、5 - 20、>20 μg/mL，这些组中获得的D - 二聚体水平分别为350 - 1210 ng/mL、420 - 1960 ng/mL和1190 - 51170 ng/mL。观察到D - 二聚体水平与FDP乳胶凝集试验中发生凝集所需的反应时间之间存在显著关联。
D - 二聚体和FDP的血浆水平之间存在关联。FDP水平的初步测定可能有用，因为它可以在自动系统分析之前估计D - 二聚体水平，降低与血浆样品稀释相关的成本。
