与低剂量甲氨蝶呤治疗类风湿关节炎相关的卡氏肺孢子虫肺炎
Pneumocystis carinii pneumonia associated with low dose methotrexate treatment for rheumatoid arthritis.
作者信息
Stenger A A, Houtman P M, Bruyn G A, Eggink H F, Pasma H R
机构信息
Department of Rheumatology, Medical Centre Leeuwarden, The Netherlands.
出版信息
Scand J Rheumatol. 1994;23(1):51-3. doi: 10.3109/03009749409102137.
Since 1983 there have been several reports on Pneumocystis carinii pneumonia (PCP), complicating low dose methotrexate (MTX) therapy for rheumatoid arthritis (RA). Two additional cases of this opportunistic infection are reported and a review of the literature on the complication is presented. It is concluded that PCP is a serious complication of low dose MTX therapy for RA and should always be ruled out when a patient presents with pulmonary symptoms. Several factors may play a role in the occurrence of this opportunistic infection, but the exact mechanism has not yet been elucidated.
自1983年以来，已有多篇关于卡氏肺孢子虫肺炎（PCP）的报告，该疾病使类风湿关节炎（RA）的低剂量甲氨蝶呤（MTX）治疗变得复杂。本文报告了另外两例这种机会性感染的病例，并对有关该并发症的文献进行了综述。得出的结论是，PCP是RA低剂量MTX治疗的一种严重并发症，当患者出现肺部症状时应始终排除该疾病。多种因素可能在这种机会性感染的发生中起作用，但确切机制尚未阐明。
Zotero 插件