使用EPIC食物频率问卷对帕金森病患者蛋白质摄入量的研究

Protein intake in Parkinsonian patients using the EPIC food frequency questionnaire.

作者信息

Marczewska Agnieszka, De Notaris Roberta, Sieri Sabina, Barichella Michela, Fusconi Elisabetta, Pezzoli Gianni

机构信息

Istituti Clinici di Perfezionamento, Parkinson Institute, Milan, Italy.

出版信息

Mov Disord. 2006 Aug;21(8):1229-31. doi: 10.1002/mds.20888.

DOI:10.1002/mds.20888

PMID:16622857

Abstract

The dietary habits of 45 Italian patients with Parkinson's disease (PD) and their spouses were investigated using the EPIC food frequency questionnaire. Average daily energy intake was similar, but PD patients consumed significantly more vegetable proteins and carbohydrates (both +18%; P = 0.01 and P = 0.001, respectively). Daily protein intake, which interferes with levodopa absorption, was 50% higher than the recommended daily allowance (1.2 vs. 0.8 g/kg) in both PD patients and spouses and was significantly higher in patients with moderate/severe symptoms (1.27 +/- 0.29 vs. 1.07 +/- 0.28 g/kg; P < 0.001). In patients taking levodopa, there was a correlation between daily levodopa dosage and protein intake (P = 0.027). Dietary habits of patients with advanced and/or fluctuating PD should always be checked, with particular reference to protein intake.

摘要

采用欧洲癌症与营养前瞻性调查（EPIC）食物频率问卷对45名意大利帕金森病（PD）患者及其配偶的饮食习惯进行了调查。平均每日能量摄入量相似，但PD患者摄入的植物蛋白和碳水化合物明显更多（均增加18%；P值分别为0.01和0.001）。干扰左旋多巴吸收的每日蛋白质摄入量在PD患者及其配偶中均比推荐的每日摄入量高50%（分别为1.2 vs. 0.8 g/kg），且中度/重度症状患者的摄入量显著更高（1.27±0.29 vs. 1.07±0.28 g/kg；P<0.001）。在服用左旋多巴的患者中，每日左旋多巴剂量与蛋白质摄入量之间存在相关性（P = 0.027）。对于晚期和/或症状波动的PD患者，应始终检查其饮食习惯，尤其要关注蛋白质摄入量。