Logroscino G, Marder K, Cote L, Tang M X, Shea S, Mayeux R
Gertrude H. Sergievsky Center, New York, NY 10032, USA.
Ann Neurol. 1996 Jan;39(1):89-94. doi: 10.1002/ana.410390113.
Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). In a population-based, case-control study we examined whether dietary intake of antioxidants and other oxidative compounds was associated with PD. Dietary intake was assessed by a semiquantitative food-frequency questionnaire in 110 PD case patients and 287 control subjects. A higher caloric intake was observed in patients with PD and did not vary with increasing duration of symptoms. Energy-adjusted fat intake was significantly higher among patients with PD than control subjects (p for trend = 0.007). Intake of protein (p for trend = 0.17) and carbohydrates (p for trend = 0.46) did not differ in patients and control subjects. Analyses of the primary sources of fat indicated that increasing intake of animal fats were strongly related to PD (odds ratio, 5.3; 95% confidence interval, 1.8-15.5; p for trend = 0.001). No significant differences were observed for intake of vitamins with antioxidant activity. An increase in the consumption of animal fats among patients with PD is consistent with the hypothesis that oxidative stress and lipid peroxidation are important in the pathogenesis of this disease. No effect of vitamins with antioxidant activity, either from food or supplements, was observed.
氧化应激在帕金森病（PD）的发病机制中起重要作用。在一项基于人群的病例对照研究中，我们研究了抗氧化剂和其他氧化化合物的饮食摄入量是否与PD相关。通过半定量食物频率问卷对110例PD病例患者和287名对照受试者的饮食摄入量进行了评估。观察到PD患者的热量摄入量较高，且不随症状持续时间的增加而变化。PD患者经能量调整后的脂肪摄入量显著高于对照受试者（趋势p值=0.007）。患者和对照受试者的蛋白质摄入量（趋势p值=0.17）和碳水化合物摄入量（趋势p值=0.46）没有差异。对脂肪主要来源的分析表明，动物脂肪摄入量的增加与PD密切相关（比值比，5.3；95%置信区间，1.8 - 15.5；趋势p值=0.001）。具有抗氧化活性的维生素摄入量未观察到显著差异。PD患者动物脂肪消耗量的增加与氧化应激和脂质过氧化在该疾病发病机制中起重要作用的假设一致。未观察到来自食物或补充剂的具有抗氧化活性的维生素有任何作用。
