大鼠前庭神经节中的潜伏性单纯疱疹病毒I型感染。

Latent HSV-I infection in rat vestibular ganglia.

作者信息

Shimogori H, Sekitani T, Koyanagi Y, Yamamoto N

机构信息

Department of Otorhinolaryngology, Yamaguchi University School of Medicine, Ube, Japan.

出版信息

Acta Otolaryngol. 1991;111(6):1031-6. doi: 10.3109/00016489109100752.

DOI:10.3109/00016489109100752

PMID:1662455

Abstract

The vestibular ganglia of rats having no clinical symptoms after inoculation of HSV-I were examined by Polymerase Chain Reaction (PCR) in order to prove latent HSV-I infection. The rats were divided into two groups: one inoculated with HSV-I into the middle ear cavity (m.i. group), and the other into the peritoneal space (i.p. group). In the m.i. group, 67% of the vestibular ganglia on the inoculated side and 0% on the opposite side were positive. In the i.p. group, 60% of the vestibular ganglia on both sides were positive. These data indicate that HSV-I can establish latent infection in the vestibular ganglia. Furthermore, we assumed that reactivation of HSV-I genomes in the vestibular ganglia might lead to disorders of the vestibular system.

摘要

为了证实单纯疱疹病毒I型（HSV-I）的潜伏感染，对接种HSV-I后无临床症状的大鼠的前庭神经节进行了聚合酶链反应（PCR）检测。大鼠被分为两组：一组经中耳腔接种HSV-I（中耳接种组），另一组经腹腔接种（腹腔接种组）。在中耳接种组中，接种侧前庭神经节的阳性率为67%，对侧为0%。在腹腔接种组中，两侧前庭神经节的阳性率均为60%。这些数据表明HSV-I可在前庭神经节建立潜伏感染。此外，我们推测前庭神经节中HSV-I基因组的重新激活可能导致前庭系统紊乱。