Zamarrón-Sanz Carlos, Ricoy-Galbaldon Jorge, Gude-Sampedro Francisco, Riveiro-Riveiro Alberto
Department of Medicine, Hospital Clinico Universitario, Santiago de Compostela, Spain.
Arch Med Res. 2006 May;37(4):552-5. doi: 10.1016/j.arcmed.2005.10.011.
Although the link between obstructive sleep apnea syndrome and risk for cardiovascular disorders has yet to be fully described, the hypothetical involvement of endothelial dysfunction is pathophysiologically plausible. In order to test this hypothesis, we measured plasma levels of endothelial markers in 82 male subjects (41 subjects with obstructive sleep apnea syndrome and a 41-subject control group). Obstructive sleep apnea syndrome patients presented higher circulating levels of intercellular cell adhesion molecule-1, E-selectin, and endothelin-1 than the control group. On the other hand, no differences were found in the von Willebrand factor. Levels of E-selectin and intercellular cell adhesion molecule-1 were significantly correlated to total oxygen desaturation. However, no significant correlation was found in either endothelin-1 or von Willebrand factor. We conclude that obstructive sleep apnea syndrome is associated with changes in levels of adhesion molecules, and that this could be the result of obstructive sleep apnea syndrome-induced hypoxia.
尽管阻塞性睡眠呼吸暂停综合征与心血管疾病风险之间的联系尚未完全阐明，但从病理生理学角度来看，内皮功能障碍的假设性参与是合理的。为了验证这一假设，我们测量了82名男性受试者（41名阻塞性睡眠呼吸暂停综合征患者和41名作为对照组的受试者）血浆中的内皮标志物水平。与对照组相比，阻塞性睡眠呼吸暂停综合征患者的细胞间黏附分子-1、E-选择素和内皮素-1的循环水平更高。另一方面，血管性血友病因子水平未发现差异。E-选择素和细胞间黏附分子-1的水平与总氧饱和度显著相关。然而，内皮素-1或血管性血友病因子均未发现显著相关性。我们得出结论，阻塞性睡眠呼吸暂停综合征与黏附分子水平的变化有关，这可能是阻塞性睡眠呼吸暂停综合征引起的缺氧所致。
