Golding C V P, Danchaivijitr C, Hodgson T L, Tabrizi S J, Kennard C
Department of Clinical Neuroscience, Faculty of Medicine, Imperial College, London, UK.
Neurology. 2006 Aug 8;67(3):485-7. doi: 10.1212/01.wnl.0000218215.43328.88. Epub 2006 Apr 19.
The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.
作者们检测了眼动功能，以确定基因确诊的临床前和早期临床亨廷顿病（HD）疾病进展的生物标志物。临床前HD的特征是自主引导性扫视（而非反射性扫视）起始缺陷。临床HD表现出扫视减慢和反射性扫视延迟，但临床前HD未出现。扫视测量为HD临床前和早期临床阶段的疾病进展提供了生物标志物。
