Khan Nazoora, Sood Priti, Vasenwala Shaista M, Afroz Nishat, Verma A K
Department of Pathology, J N Medical College, AMU, Aligarh.
Indian J Pathol Microbiol. 2006 Jan;49(1):17-20.
AgNOR staining was employed on FNAC and histopathological sections obtained from patients with soft tissue tumours. The study comprised of 20 normal appearing soft tissues, 74 benign and 36 malignant soft tissue tumours. The slides were stained with AgNOR in order to differentiate between benign and malignant soft tissue tumours. The mean AgNOR count in normal appearing soft tissues, benign lesions and malignant lesions was 1.04+/-0.10 (0.94-1.14), 1.51+/-0.21 (1.1-2.1) and 4.96+/-1.33 (2.57-7.21) respectively. The mean AgNOR count was found to be higher in benign soft tissue tumours as compared to normal appearing soft tissues and the difference was found to be statistically significant. The mean AgNOR count in soft tissue sarcomas was found to be higher as compared to both normal appearing soft tissues and benign soft tissue tumours and the results were found to be statistically significant. The increased AgNOR score in both benign and malignant soft tissue tumours as compared to normal appearing soft tissues indicates high proliferative activity. Thus AgNOR staining is a simple and useful method for estimating tumour cell proliferation thereby differentiating normal appearing soft tissues from benign and malignant soft tissue tumours.
对从软组织肿瘤患者获取的细针穿刺抽吸活检（FNAC）样本及组织病理学切片进行了核仁组成区嗜银蛋白（AgNOR）染色。该研究包括20个外观正常的软组织、74个良性和36个恶性软组织肿瘤。为区分良性和恶性软组织肿瘤，对玻片进行了AgNOR染色。外观正常的软组织、良性病变和恶性病变中的平均AgNOR计数分别为1.04±0.10（0.94 - 1.14）、1.51±0.21（1.1 - 2.1）和4.96±1.33（2.57 - 7.21）。发现良性软组织肿瘤中的平均AgNOR计数高于外观正常的软组织，且差异具有统计学意义。发现软组织肉瘤中的平均AgNOR计数高于外观正常的软组织和良性软组织肿瘤，结果具有统计学意义。与外观正常的软组织相比，良性和恶性软组织肿瘤中AgNOR评分的增加表明增殖活性较高。因此，AgNOR染色是一种简单且有用的方法，用于评估肿瘤细胞增殖，从而区分外观正常的软组织与良性和恶性软组织肿瘤。
