Laiquzzaman Mohammad, Bhojwani Rajan, Cunliffe Ian, Shah Sunil
Birmingham Heartlands and Solihull NHS Trust, Solihull, UK.
Clin Exp Ophthalmol. 2006 Mar;34(2):114-8. doi: 10.1111/j.1442-9071.2006.01185.x.
This study was conducted to assess the diurnal variation in ocular hysteresis, as measured by the Ocular Response Analyser to establish a relationship between diurnal hysteresis variation and diurnal intraocular pressure (IOP) variation.
Forty-two normal eyes of 21 colleagues and staff in a teaching hospital in Birmingham, UK, were recruited. The IOP and hysteresis were measured by the Ocular Response Analyser. The central corneal thickness (CCT) was measured using a hand-held ultrasonic pachymeter in the mid-pupillary axis.
The mean ocular hysteresis at 8 am was 12.7 +/- 2.3 mmHg, at 11 am was 12.2 +/- 2.0 mmHg, at 2 PM was 12.7 +/- 2.1 mmHg and at 5 PM was 12.7 +/- 1.7 mmHg; the difference between the values at any time of measurement was not statistically significant (P > 0.9, repeated measures). IOP as measured by non-contact tonometry was 18.4 +/- 2.8 mmHg, 17.9 +/- 3.3 mmHg, 16.9 +/- 3.1 mmHg and 16.8 +/- 3.2 mmHg, respectively, for the same time period; the difference between the values in the morning and afternoon was statistically significant (P < 0.0001, repeated measures). The CCT was 548.8 +/- 29.5 microm, 547.0 +/- 31.4 microm, 548.2 +/- 29.6 microm and 548.6 +/- 29.4 microm, respectively; the difference between the values was not statistically significant at any time points. Multiple regression analysis showed the relationship between IOP and hysteresis was not statistically significant (P = 0.9).
The ocular hysteresis reading was almost constant throughout the day, whereas the IOP readings showed highest values in the morning with a reducing trend being lowest in the afternoon. The CCT values were almost stable throughout the day. IOP appears to vary independently of a variation in hysteresis or CCT.
本研究旨在评估通过眼反应分析仪测量的眼滞后的昼夜变化，以建立昼夜滞后变化与昼夜眼压（IOP）变化之间的关系。
招募了英国伯明翰一家教学医院的21名同事和工作人员的42只正常眼睛。使用眼反应分析仪测量眼压和滞后。在瞳孔中轴使用手持超声测厚仪测量中央角膜厚度（CCT）。
上午8点时平均眼滞后为12.7±2.3mmHg，上午11点时为12.2±2.0mmHg，下午2点时为12.7±2.1mmHg，下午5点时为12.7±1.7mmHg；任何测量时间的值之间的差异无统计学意义（P>0.9，重复测量）。同一时间段内，非接触眼压计测量的眼压分别为18.4±2.8mmHg、17.9±3.3mmHg、16.9±3.1mmHg和16.8±3.2mmHg；上午和下午的值之间的差异有统计学意义（P<0.0001，重复测量）。CCT分别为548.8±29.5微米、547.0±31.4微米、548.2±29.6微米和548.6±29.4微米；各时间点的值之间的差异无统计学意义。多元回归分析显示眼压与滞后之间的关系无统计学意义（P=0.9）。
眼滞后读数全天几乎恒定，而眼压读数上午最高，呈下降趋势，下午最低。CCT值全天几乎稳定。眼压似乎独立于滞后或CCT的变化而变化。
