• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

种子提取物对小鼠扑热息痛中毒的抗氧化和抗肝毒性活性的氧化还原调控：草药绿色抗氧化剂的体外和体内研究

Redox Control of Antioxidant and Antihepatotoxic Activities of Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant.

作者信息

Uthaya Kumar U Seeta, Chen Yeng, Kanwar Jagat R, Sasidharan Sreenivasan

机构信息

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), 11800 Pulau Pinang, Malaysia.

Dental Research & Training Unit and Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Oxid Med Cell Longev. 2016;2016:6841348. doi: 10.1155/2016/6841348. Epub 2016 Dec 8.

DOI:10.1155/2016/6841348
PMID:28053693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5178853/
Abstract

The therapeutic potential of in reducing free radical-induced oxidative stress and inflammation particularly in hepatic diseases was evaluated in this study. The polyphenol rich seed extract showed good in vitro antioxidant. seed extract contained total phenolic content of 100.99 mg GAE/g dry weight and there was a positive correlation ( > 0.9) between total phenolic content and the antioxidant activities of the seed extract. seed extract significantly ( < 0.05) reduced the elevated levels of serum liver enzymes (ALT, AST, and ALP) and relative liver weight in paracetamol-induced liver hepatotoxicity in mice. Moreover, the extract significantly ( < 0.05) enhanced the antioxidant enzymes and glutathione (GSH) contents in the liver tissues, which led to decrease of malondialdehyde (MDA) level. The histopathological examination showed the liver protective effect of seed extract against paracetamol-induced histoarchitectural alterations by maximum recovery in the histoarchitecture of the liver tissue. Furthermore, histopathological observations correspondingly supported the biochemical assay outcome, that is, the significant reduction in elevated levels of serum liver enzymes. In conclusion, seed extract enhanced the in vivo antioxidant status and showed antihepatotoxic activities, which is probably due to the presence of phenolic compounds.

摘要

本研究评估了[具体物质]在减轻自由基诱导的氧化应激和炎症方面的治疗潜力，尤其是在肝脏疾病中的作用。富含多酚的[具体种子]提取物在体外表现出良好的抗氧化性能。[具体种子]提取物的总酚含量为100.99毫克没食子酸当量/克干重，且总酚含量与种子提取物的抗氧化活性之间存在正相关（>0.9）。在对乙酰氨基酚诱导的小鼠肝脏肝毒性实验中，[具体种子]提取物显著（<0.05）降低了血清肝酶（谷丙转氨酶、谷草转氨酶和碱性磷酸酶）水平的升高以及相对肝脏重量。此外，该提取物显著（<0.05）提高了肝脏组织中的抗氧化酶和谷胱甘肽（GSH）含量，从而导致丙二醛（MDA）水平降低。组织病理学检查显示，[具体种子]提取物对乙酰氨基酚诱导的组织架构改变具有肝脏保护作用，肝脏组织的组织结构得到了最大程度的恢复。此外，组织病理学观察相应地支持了生化检测结果，即血清肝酶水平升高的显著降低。总之，[具体种子]提取物提高了体内抗氧化状态并显示出抗肝毒性活性，这可能归因于酚类化合物的存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/220d22820095/OMCL2016-6841348.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/2e82585c5094/OMCL2016-6841348.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/84e177a219fc/OMCL2016-6841348.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/d6b3d38c97c8/OMCL2016-6841348.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/fe5ad5e2da28/OMCL2016-6841348.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/689e1d91a7bc/OMCL2016-6841348.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/839c7265dc3d/OMCL2016-6841348.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/b6dc2efa02e4/OMCL2016-6841348.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/826543911184/OMCL2016-6841348.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/31448aa5e9c8/OMCL2016-6841348.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/220d22820095/OMCL2016-6841348.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/2e82585c5094/OMCL2016-6841348.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/84e177a219fc/OMCL2016-6841348.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/d6b3d38c97c8/OMCL2016-6841348.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/fe5ad5e2da28/OMCL2016-6841348.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/689e1d91a7bc/OMCL2016-6841348.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/839c7265dc3d/OMCL2016-6841348.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/b6dc2efa02e4/OMCL2016-6841348.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/826543911184/OMCL2016-6841348.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/31448aa5e9c8/OMCL2016-6841348.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6863/5178853/220d22820095/OMCL2016-6841348.010.jpg

相似文献

1
Redox Control of Antioxidant and Antihepatotoxic Activities of Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant.种子提取物对小鼠扑热息痛中毒的抗氧化和抗肝毒性活性的氧化还原调控：草药绿色抗氧化剂的体外和体内研究
Oxid Med Cell Longev. 2016;2016:6841348. doi: 10.1155/2016/6841348. Epub 2016 Dec 8.
2
A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo.金狗尾草中富含原花青素的提取物在体内具有抗氧化和保肝活性。
J Ethnopharmacol. 2018 Mar 1;213:38-47. doi: 10.1016/j.jep.2017.11.007. Epub 2017 Nov 7.
3
Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice.石榴花提取物具有强大的抗氧化活性，并可消除铁-亚硝基三乙酸诱导的小鼠肝毒性。
Food Chem Toxicol. 2006 Jul;44(7):984-93. doi: 10.1016/j.fct.2005.12.001. Epub 2006 Jan 19.
4
Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature.辣木的水醇提取物通过其抗氧化特性，有效地缓解了实验大鼠的对乙酰氨基酚诱导的肝毒性。
Molecules. 2012 Jul 10;17(7):8334-50. doi: 10.3390/molecules17078334.
5
Evaluation of antioxidant activity of Cassia siamea flowers.暹罗决明花抗氧化活性的评估
J Ethnopharmacol. 2006 Dec 6;108(3):340-8. doi: 10.1016/j.jep.2006.05.021. Epub 2006 Jun 12.
6
Antioxidant and anti-fatigue activities of phenolic extract from the seed coat of Euryale ferox Salisb. and identification of three phenolic compounds by LC-ESI-MS/MS.芡实种皮酚类提取物的抗氧化和抗疲劳活性及三种酚类化合物的 LC-ESI-MS/MS 鉴定
Molecules. 2013 Sep 9;18(9):11003-21. doi: 10.3390/molecules180911003.
7
Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats.蛋黄果对大鼠对乙酰氨基酚诱导的肝毒性的抗氧化和肝保护潜力。
J Physiol Biochem. 2014 Mar;70(1):1-14. doi: 10.1007/s13105-013-0274-3. Epub 2013 Jul 20.
8
In vitro antioxidant and hepatoprotective activities of Paeonia emodi (Wall.) rhizome methanol extract and its phenolic compounds rich fractions.墨紫芍药根茎甲醇提取物及其富含酚类化合物的馏分的体外抗氧化和肝脏保护活性
Pak J Pharm Sci. 2016 Sep;29(5 Suppl):1787-1794.
9
Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.核桃 Juglans regia L. 对人癌细胞的抗增殖和抗氧化活性
Food Chem Toxicol. 2010 Jan;48(1):441-7. doi: 10.1016/j.fct.2009.10.043. Epub 2009 Oct 31.
10
Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.三叶鬼针草叶提取物对乙酰氨基酚诱导的小鼠肝损伤的保护作用。
Molecules. 2011 Dec 6;16(12):10134-45. doi: 10.3390/molecules161210134.

引用本文的文献

1
Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches.咖啡酸减轻戊四氮诱导的急性惊厥通过调节 NLRP3 炎性小体和钙/钙调神经磷酸酶信号：体内和计算机模拟方法。
Inflammation. 2024 Dec;47(6):1969-1986. doi: 10.1007/s10753-024-02019-0. Epub 2024 Apr 25.
2
Photophysical Properties of Sinapic Acid and Ferulic Acid and Their Binding Mechanism with Caffeine.芥子酸和阿魏酸的光物理性质及其与咖啡因的结合机制
J Fluoresc. 2025 Apr;35(4):2379-2393. doi: 10.1007/s10895-024-03689-7. Epub 2024 Apr 9.
3
Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum.

本文引用的文献

1
Yin and Yang of Polyphenols in Cancer Prevention: A Short Review.多酚在癌症预防中的阴阳学说：简短综述
Anticancer Agents Med Chem. 2016;16(7):832-40. doi: 10.2174/1871520616666151116124549.
2
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies.多酚作为癌症疾病氧化应激的调节剂：新的治疗策略。
Oxid Med Cell Longev. 2016;2016:6475624. doi: 10.1155/2016/6475624. Epub 2015 Nov 16.
3
Phytochemical regulation of Fyn and AMPK signaling circuitry.植物化学物质对 Fyn 和 AMPK 信号通路的调节。
从传统医学中使用的药用植物中分离生物活性化合物：Rautandiol B，一种针对恶性疟原虫的潜在先导化合物。
BMC Complement Med Ther. 2021 Sep 13;21(1):231. doi: 10.1186/s12906-021-03406-y.
4
The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?抗氧化特性植物制剂的巨大治愈潜力：回归自然？
Oxid Med Cell Longev. 2020 Oct 9;2020:8163868. doi: 10.1155/2020/8163868. eCollection 2020.
5
Aldose reductase inhibitor form Cassia glauca: A comparative study of cytotoxic activity with Ag nanoparticles (NPs) and molecular docking evaluation.阿洛酮糖还原酶抑制剂的研究进展：基于构树水提物对细胞毒性的对比研究及其与银纳米粒子（NPs）的分子对接评价。
PLoS One. 2020 Oct 16;15(10):e0240856. doi: 10.1371/journal.pone.0240856. eCollection 2020.
Arch Pharm Res. 2015 Dec;38(12):2093-105. doi: 10.1007/s12272-015-0611-x. Epub 2015 May 8.
4
Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice.菠萝醋对乙酰氨基酚诱导的小鼠肝损伤的抗氧化逆转作用。
Chin Med. 2015 Feb 13;10:3. doi: 10.1186/s13020-015-0030-4. eCollection 2015.
5
Hepatoprotective and in vivo antioxidant activities of the hydroethanolic leaf extract of Mucuna pruriens (Fabaceae) in antitubercular drugs and alcohol models.水醇提豨莶草（黎豆科）叶提取物对结核药物和酒精模型的肝保护和体内抗氧化活性。
Chin J Nat Med. 2014 Apr;12(4):273-83. doi: 10.1016/S1875-5364(14)60054-6.
6
Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats.紫荆叶甲醇提取物对乙酰氨基酚诱导的大鼠肝损伤的保护作用。
Evid Based Complement Alternat Med. 2013;2013:636580. doi: 10.1155/2013/636580. Epub 2013 Jun 18.
7
Evaluation of the effect of Cassia surattensis Burm. f., flower methanolic extract on the growth and morphology of Aspergillus niger.评价决明子花甲醇提取物对黑曲霉生长和形态的影响。
Eur Rev Med Pharmacol Sci. 2013 Jun;17(12):1648-54.
8
Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants.评估水醇法和煎煮法对从选定的印度药用植物中提取抗氧化剂的效果。
Asian Pac J Trop Biomed. 2012 Mar;2(3):195-202. doi: 10.1016/S2221-1691(12)60041-0.
9
Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice.杠板归对酒精性肝损伤的保护作用。
Evid Based Complement Alternat Med. 2012;2012:417953. doi: 10.1155/2012/417953. Epub 2012 Aug 29.
10
Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts.活性氧与炎症性肝损伤的机制：当前观点。
J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:173-9. doi: 10.1111/j.1440-1746.2010.06592.x.