Gonzalez Sara L, Grave de Peralta Rolando, Thut Gregor, Millán José del R, Morier Patrice, Landis Theodor
Electrical Neuroimaging Group, Neurology Department, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland.
Neuroimage. 2006 Aug 1;32(1):170-9. doi: 10.1016/j.neuroimage.2006.02.041. Epub 2006 May 2.
Gamma band (30-80 Hz) oscillations arising in neuronal ensembles are thought to be a crucial component of the neural code. Recent studies in animals suggest a similar functional role for very high frequency oscillations (VHFO) in the range 80-200 Hz. Since some intracerebral studies in humans link VHFO to epileptogenesis, it remains unclear if VHFO appear in the healthy human brain and if so which is their role. This study uses EEG recordings from twelve healthy volunteers, engaged in a visuo-motor reaction time task, to show that VHFO are not necessarily pathological but rather code information about upcoming movements. Oscillations within the range (30-200 Hz) occurring in the period between stimuli presentation and the fastest hand responses allow highly accurate (>96%) prediction of the laterality of the responding hand in single trials. Our results suggest that VHFO belong in functional terms to the gamma band that must be considerably enlarged to better understand the role of oscillatory activity in brain functioning. This study has therefore important implications for the recording and analysis of electrophysiological data in normal subjects and patients.
神经元群体中产生的伽马波段（30 - 80赫兹）振荡被认为是神经编码的关键组成部分。最近对动物的研究表明，80 - 200赫兹范围内的极高频振荡（VHFO）具有类似的功能作用。由于一些针对人类的脑内研究将VHFO与癫痫发生联系起来，目前尚不清楚VHFO是否出现在健康人类大脑中，如果出现，它们的作用是什么。本研究使用了12名健康志愿者在进行视觉运动反应时间任务时的脑电图记录，以表明VHFO不一定是病理性的，而是编码有关即将发生运动的信息。在刺激呈现和最快的手部反应之间的时间段内出现的（30 - 200赫兹）范围内的振荡，能够在单次试验中高度准确地（>96%）预测反应手的偏侧性。我们的结果表明，从功能角度来看，VHFO属于伽马波段，必须大幅扩大该波段范围，以便更好地理解振荡活动在大脑功能中的作用。因此，本研究对正常受试者和患者的电生理数据记录与分析具有重要意义。
