Caplan Jay D, Waxman Sergio, Nesto Richard W, Muller James E
InfraReDx Inc., Burlington, Massachusetts 01803, USA.
J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C92-6. doi: 10.1016/j.jacc.2005.12.045.
This review describes efforts to use near-infrared (NIR) spectroscopy to identify chemical components of coronary artery plaques as a means to assess vulnerability. Near-infrared spectroscopy has been well-validated by the physical sciences as a method to characterize chemical composition of various bio-materials and could be ideal to detect vulnerable coronary plaques in patients. Recent studies in aortic and coronary artery autopsy specimens have confirmed the ability of the technique to identify lipid-rich thin-cap fibroatheromas through blood. A catheter-based system has been developed to address the challenges-of access to the coronary artery, blood, motion, and the need to scan-that must be overcome for use in patients. Initial clinical experience in six patients with stable angina demonstrates that high-quality NIR spectra can be safely obtained. Additional studies are planned to validate the ability of the technique to identify lipid-rich coronary artery plaques and ultimately link chemical characterization with subsequent occurrence of an acute coronary syndrome.
本综述描述了利用近红外（NIR）光谱法识别冠状动脉斑块化学成分以评估其易损性的相关研究。近红外光谱法作为一种表征各种生物材料化学成分的方法，已得到物理科学的充分验证，可能是检测患者易损冠状动脉斑块的理想方法。近期对主动脉和冠状动脉尸检标本的研究证实了该技术通过血液识别富含脂质的薄帽纤维粥样斑块的能力。为应对冠状动脉、血液、运动以及扫描需求等方面的挑战，已开发出一种基于导管的系统，以便在患者中使用。对6例稳定型心绞痛患者的初步临床经验表明，可以安全地获取高质量的近红外光谱。计划开展更多研究以验证该技术识别富含脂质的冠状动脉斑块的能力，并最终将化学特征与随后急性冠状动脉综合征的发生联系起来。
