Lang Carolyn A, Conrad Sue, Garrett Lyndall, Battistutta Diana, Cooksley W Graham E, Dunne Michael P, Macdonald Graeme A
Center for Diabetes and Endocrine Research, The University of Queensland, Queensland, Australia.
J Pain Symptom Manage. 2006 Apr;31(4):335-44. doi: 10.1016/j.jpainsymman.2005.08.016.
Quality of life has been shown to be poor among people living with chronic hepatitis C. However, it is not clear how this relates to the presence of symptoms and their severity. The aim of this study was to describe the typology of a broad array of symptoms that were attributed to hepatitis C virus (HCV) infection. Phase 1 used qualitative methods to identify symptoms. In Phase 2, 188 treatment-naïve people living with HCV participated in a quantitative survey. The most prevalent symptom was physical tiredness (86%) followed by irritability (75%), depression (70%), mental tiredness (70%), and abdominal pain (68%). Temporal clustering of symptoms was reported in 62% of participants. Principal components analysis identified four symptom clusters: neuropsychiatric (mental tiredness, poor concentration, forgetfulness, depression, irritability, physical tiredness, and sleep problems); gastrointestinal (day sweats, nausea, food intolerance, night sweats, abdominal pain, poor appetite, and diarrhea); algesic (joint pain, muscle pain, and general body pain); and dysesthetic (noise sensitivity, light sensitivity, skin problems, and headaches). These data demonstrate that symptoms are prevalent in treatment-naïve people with HCV and support the hypothesis that symptom clustering occurs.
已有研究表明，慢性丙型肝炎患者的生活质量较差。然而，目前尚不清楚这与症状的存在及其严重程度之间有何关联。本研究的目的是描述一系列归因于丙型肝炎病毒（HCV）感染的症状类型。第一阶段采用定性方法识别症状。在第二阶段，188名未接受过治疗的HCV感染者参与了一项定量调查。最常见的症状是身体疲劳（86%），其次是易怒（75%）、抑郁（70%）、精神疲劳（70%）和腹痛（68%）。62%的参与者报告了症状的时间性聚集。主成分分析确定了四个症状集群：神经精神性（精神疲劳、注意力不集中、健忘、抑郁、易怒、身体疲劳和睡眠问题）；胃肠道（日间盗汗、恶心、食物不耐受、夜间盗汗、腹痛、食欲不振和腹泻）；疼痛性（关节疼痛、肌肉疼痛和全身疼痛）；以及感觉异常性（对噪音敏感、对光线敏感、皮肤问题和头痛）。这些数据表明，症状在未接受过治疗的HCV感染者中普遍存在，并支持症状聚集会发生的假设。
