砂粒体样骨化性纤维瘤：免疫组织化学分析及与颅面骨砂粒体性脑膜瘤的鉴别诊断

Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones.

作者信息

Granados Rosario, Carrillo Rosario, Nájera Laura, García-Villanueva Mercedes, Patrón Mercedes

机构信息

University Hospital of Getafe, Madrid, Spain.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 May;101(5):614-9. doi: 10.1016/j.tripleo.2005.03.036. Epub 2006 Feb 17.

DOI:10.1016/j.tripleo.2005.03.036

PMID:16632273

Abstract

OBJECTIVE

To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton.

STUDY DESIGN

The histology and immunohistochemistry of 4 PSOFs, 6 COFs, and 7 PMs was studied. Antibodies included EMA, cytokeratins, smooth muscle actin (SMA), desmin, vimentin, CD34, CD10, S-100 protein, and glial fibrillary acidic protein (GFAP).

RESULTS

All PSOFs showed multiple round ossicles homogeneously distributed within a fibroblastic stroma. Psammomatous meningiomas had meningothelial features. All tumors, except 1 COF, were positive for EMA. All of them expressed vimentin, and none showed cytokeratins. Staining for SMA and S-100 protein was variable. CD10 was positive in all cases except 2 meningiomas. CD34 and GFAP stained only 1 case of meningioma each.

CONCLUSIONS

The diagnosis of PSOF should rest on histologic features. An incorrect diagnosis of meningioma based on the expression of EMA should be avoided.

摘要

目的

阐明免疫组织化学在颅面骨沙瘤样骨化性纤维瘤（PSOF）、传统骨化性纤维瘤（COF）和沙瘤性脑膜瘤（PM）诊断中的作用。

研究设计

对4例PSOF、6例COF和7例PM进行组织学和免疫组织化学研究。抗体包括上皮膜抗原（EMA）、细胞角蛋白、平滑肌肌动蛋白（SMA）、结蛋白、波形蛋白、CD34、CD10、S-100蛋白和胶质纤维酸性蛋白（GFAP）。

结果

所有PSOF均显示多个圆形小骨，均匀分布于成纤维细胞基质内。沙瘤性脑膜瘤具有脑膜内皮特征。除1例COF外，所有肿瘤EMA均呈阳性。所有肿瘤均表达波形蛋白，无一例显示细胞角蛋白。SMA和S-100蛋白染色结果不一。除2例脑膜瘤外，CD10在所有病例中均呈阳性。CD34和GFAP仅各有1例脑膜瘤染色阳性。