Eroglu Ahmet, Celep Figen, Erciyes Nesrin
Department of Anesthesiology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
Anesth Analg. 2006 May;102(5):1573-7. doi: 10.1213/01.ane.0000204298.42159.0e.
An increased incidence of sister chromatid exchanges (SCEs) in peripheral lymphocytes of operating room personnel exposed to waste anesthetic gases has been reported. We investigated whether the increase of SCEs in anesthesiologists was reversible. Twenty-five anesthesiologists exposed to waste anesthetic gases such as sevoflurane and nitrous oxide were compared with nonexposed internists working in the same hospital. The concentrations of sevoflurane and nitrous oxide in the operating rooms were measured. The incidence of SCE was measured in lymphocytes cultures of anesthesiologists before and after a 2-mo leave from the operating room. These values of SCE were compared with those of nonexposed physicians. Occupational exposure to sevoflurane and nitrous oxide in the operating rooms were above the threshold values. There was a significant difference in SCE values of the anesthesiologists compared with the nonexposed physicians (11.9 +/- 4.4 versus 4.2 +/- 1.1, P < 0.001). After a 2-mo leave from the operating room, the SCE values of the anesthesiologists were significantly lower compared with those taken before the leave (4.8 +/- 1.8 and 11.9 +/- 4.4, respectively, P < 0.001). We conclude that the increase of SCE in anesthesiologists exposed to increased environmental concentrations of waste anesthetics gases, such as sevoflurane and nitrous oxide, are reversible if they work free from exposure for 2 mo.
据报道，接触废气麻醉剂的手术室工作人员外周淋巴细胞中姐妹染色单体交换（SCEs）的发生率增加。我们调查了麻醉医生中SCEs的增加是否可逆。将25名接触七氟醚和氧化亚氮等废气麻醉剂的麻醉医生与同一家医院未接触的内科医生进行比较。测量手术室中七氟醚和氧化亚氮的浓度。在麻醉医生离开手术室2个月前后，测量其淋巴细胞培养物中的SCE发生率。将这些SCE值与未接触的医生的SCE值进行比较。手术室中七氟醚和氧化亚氮的职业暴露高于阈值。与未接触的医生相比，麻醉医生的SCE值有显著差异（分别为11.9±4.4和4.2±1.1，P<0.001）。离开手术室2个月后，麻醉医生的SCE值与休假前相比显著降低（分别为4.8±1.8和11.9±4.4，P<0.001）。我们得出结论，如果麻醉医生在2个月内不接触废气麻醉剂，那么接触环境中七氟醚和氧化亚氮等废气麻醉剂浓度增加的麻醉医生中SCE的增加是可逆的。
