Law C L, Thompson C H, Rose B R, Cossart Y E
Sydney STD Centre, Sydney Hospital, NSW, Australia.
Genitourin Med. 1991 Dec;67(6):464-8. doi: 10.1136/sti.67.6.464.
To determine whether anal intercourse is a risk factor for anal HPV infection in women.
Results derived from clinical examination, anal cytology and HPV DNA hybridisation were correlated with data obtained from a questionnaire administered to the patients at the time of their clinical examination.
A sexually transmitted diseases (STD) clinic in Sydney, Australia.
31 women attending the clinic for HPV related problems.
A thorough history was elicited from each woman followed by physical examination of the anogenital region. Cervical and anal scrapes were collected for cytology and HPV DNA hybridisation. Of the 15 women who practised anal intercourse, a total of 12 (80%) had either clinical or subclinical HPV infection. Seven had overt anal warts, situated either internally or externally in the anal canal; and further 5 women had evidence of subclinical HPV infection as determined by positive cytological and/or HPV DNA hybridisation results on their anal scrapes. The women who did not have a history of anal intercourse had a lower (7/16, 43%), but not statistically significant, rate of anal HPV infection: five had anal warts and two had subclinical evidence of infection. No correlations were found between anal HPV infection and genital (cervical, vulval or vaginal) HPV infection; nor between the HPV typing patterns of women in either group.
The results obtained from these women do not indicate a close relationship between anal intercourse and the presence of detectable anal HPV infection.
确定肛交是否为女性肛门人乳头瘤病毒（HPV）感染的危险因素。
将临床检查、肛门细胞学检查及HPV DNA杂交的结果与患者临床检查时通过问卷调查获得的数据进行关联分析。
澳大利亚悉尼的一家性传播疾病（STD）诊所。
31名因HPV相关问题前往该诊所就诊的女性。
对每位女性进行详细病史询问，随后对肛门生殖器区域进行体格检查。采集宫颈和肛门刮片用于细胞学检查及HPV DNA杂交。在15名有肛交史的女性中，共有12名（80%）患有临床或亚临床HPV感染。7名有明显的肛门疣，位于肛管内部或外部；另外5名女性通过肛门刮片的细胞学和/或HPV DNA杂交阳性结果确定有亚临床HPV感染证据。无肛交史的女性肛门HPV感染率较低（7/16，43%），但无统计学意义：5名有肛门疣，2名有亚临床感染证据。未发现肛门HPV感染与生殖器（宫颈、外阴或阴道）HPV感染之间存在关联；两组女性的HPV分型模式之间也无关联。
从这些女性获得的结果并未表明肛交与可检测到的肛门HPV感染之间存在密切关系。
