Van Doornum G J, Prins M, Juffermans L H, Hooykaas C, van den Hoek J A, Coutinho R A, Quint W G
Municipal Health Service of Amsterdam, Department of Public Health, The Netherlands.
Genitourin Med. 1994 Aug;70(4):240-6. doi: 10.1136/sti.70.4.240.
To assess prevalence, incidence and potential risk factors of human papillomavirus (HPV) infection among heterosexual men and women with multiple partners and to identify niches of HPV-infection.
A prospective study of heterosexual men and women with multiple partners attending an STD clinic as participants in a study on HIV from May 1988 until January 1991. Routine STD examination and physical examination using colposcopy were performed, interviews with standardised questionnaires were administered. Specimens for HPV DNA detection by polymerase chain reaction were collected from multiple sites of the genital, anorectal and oral regions. In women cervical cytology was performed.
The STD Clinic of the Municipal Health Service of Amsterdam.
162 women and 85 men entered the study, 110 women and 48 men were followed up.
At entry of the study 37 (23%) women and 24 (28%) men were found positive for HPV DNA at any site. Only in one woman was oral presence of HPV DNA found during follow-up. Abnormal cervical cytology was observed in four women. In multivariate analysis, diagnosis of condylomata [odds ratio (OR) 5.61, 95% confidence interval (CI) 1.86 to 16.90)], reporting genital dermatological abnormalities (OR 3.72, 95% CI 1.38 to 9.99) and age (OR per year 0.93, 95% CI 0.88 to 0.99) predicted independently the presence of HPV DNA in women at entry of the study. In women 59 of the 99 (60%) HPV infections were observed in the genital region and 40% in the anorectal region: in men these figures were 65% and 35%, respectively. The incidence of HPV infection was 47.1 and 50.5 per 100 person-years for women and men respectively. At least 20/99 (20%) infections in women were intermediate or long persistent and only 3/48 (6%) HPV infections in men (P = 0.03). No risk factor for persistency could be determined, either in women or in men.
HPV infection was found to be a multicentric genital and/or anorectal event both in women and men. The oral presence of HPV DNA was detected only once in one of the participants. In women persistent HPV infection was more common than in men. Independent predictors for presence of HPV DNA in women were diagnosis of condylomata acuminata, reporting genital dermatologic abnormalities and age. Incidence of HPV infection in women turned out to be 47.1 infections per 100 person-years and for men 50.5 per 100 person-years.
评估有多个性伴侣的异性恋男性和女性中人类乳头瘤病毒（HPV）感染的患病率、发病率及潜在风险因素，并确定HPV感染的特点。
一项对有多个性伴侣的异性恋男性和女性进行的前瞻性研究。这些参与者于1988年5月至1991年1月期间在一家性传播疾病（STD）诊所参与一项关于HIV的研究。进行了常规的STD检查和使用阴道镜的体格检查，并采用标准化问卷进行访谈。通过聚合酶链反应从生殖器、肛门直肠和口腔区域的多个部位采集HPV DNA检测样本。对女性进行了宫颈细胞学检查。
阿姆斯特丹市卫生服务的STD诊所。
162名女性和85名男性进入研究，110名女性和48名男性接受随访。
在研究开始时，发现37名（23%）女性和24名（28%）男性在任何部位的HPV DNA检测呈阳性。随访期间仅在一名女性中发现口腔中有HPV DNA。4名女性观察到宫颈细胞学异常。在多变量分析中，尖锐湿疣诊断（优势比[OR] 5.61，95%置信区间[CI] 1.86至16.90）、报告生殖器皮肤异常（OR 3.72，95% CI 1.38至9.99）和年龄（每年OR 0.93，95% CI 0.88至0.99）可独立预测研究开始时女性HPV DNA的存在情况。在女性中，99例HPV感染中有59例（60%）发生在生殖器区域，40%发生在肛门直肠区域；在男性中，这些数字分别为65%和35%。女性和男性的HPV感染发病率分别为每100人年47.1例和50.5例。女性中至少20/99（20%）的感染为中度或长期持续感染，而男性中只有3/48（6%）的HPV感染（P = 0.03）。在女性或男性中均未确定持续性感染的风险因素。
发现HPV感染在女性和男性中都是多中心的生殖器和/或肛门直肠感染事件。仅在一名参与者中检测到一次口腔中有HPV DNA。女性中持续性HPV感染比男性更常见。女性HPV DNA存在的独立预测因素是尖锐湿疣诊断、报告生殖器皮肤异常和年龄。女性HPV感染发病率为每100人年47.1例，男性为每100人年50.5例。
