Zhu W Y, Leonardi C, Kinsey W, Penneys N S
Department of Dermatology, University of Miami School of Medicine, Florida.
J Cutan Pathol. 1991 Dec;18(6):449-52. doi: 10.1111/j.1600-0560.1991.tb01383.x.
Sections from paraffin-embedded tissues of lesions thought to represent verrucous lesions (benign verrucous acanthomas: BVA) as well as materials from controls including seborrheic keratoses (SK), irritated SK, and verruca vulgaris from areas other than the genitalia were analyzed for the presence of multiple human papillomaviruses (HPV) including types 6, 11, 16, 18, and 33 using DNA amplification methodology. HPV DNA sequences were not found in amplified samples of BVA, SK, and irritated SK samples, but were identified in those obtained from verruca vulgaris. Our results suggest that BVA, SK, and irritated SK are generally not associated with HPV DNA even though certain of these lesions may histologically mimic the architecture of verruca.
对认为代表疣状病变（良性疣状棘皮瘤：BVA）的石蜡包埋组织切片以及来自对照的材料进行分析，这些对照材料包括脂溢性角化病（SK）、刺激性SK以及来自生殖器以外区域的寻常疣，采用DNA扩增方法检测是否存在多种人乳头瘤病毒（HPV），包括6型、11型、16型、18型和33型。在BVA、SK和刺激性SK样本的扩增样品中未发现HPV DNA序列，但在寻常疣获得的样本中鉴定出了HPV DNA序列。我们的结果表明，BVA、SK和刺激性SK通常与HPV DNA无关，尽管这些病变中的某些在组织学上可能模仿疣的结构。
