Tao Chunrong, Simpson Steve, Taylor Bruce V, van der Mei Ingrid
Menzies Institute for Medical Research, University of Tasmania, Australia.
Menzies Institute for Medical Research, University of Tasmania, Australia.
J Neurol Sci. 2017 Jan 15;372:239-249. doi: 10.1016/j.jns.2016.11.060. Epub 2016 Nov 24.
This review discusses the role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and human endogenous retroviruses (HERVs) in the onset and progression of multiple sclerosis (MS). Although EBV has been established as one of the causal factors in MS onset, its role in MS progression is still uncertain. Moreover, interactions between EBV and other risk factor on MS development still need more investment. With less consistent evidence than EBV, HHV6 has also been implicated in the pathogenesis of MS; moreover, it showed a closer connection with the disease activity. Recent studies found that HERVs were associated with the development and progression of MS. Some antiviral treatments have shown promise for clinical interventions in the future. Future studies are yet needed to fully clarify the role of these agents in MS onset and disease course and the modes by which they realise these effects.
本综述讨论了爱泼斯坦-巴尔病毒（EBV）、人类疱疹病毒6型（HHV6）和人类内源性逆转录病毒（HERV）在多发性硬化症（MS）发病和进展中的作用。虽然EBV已被确认为MS发病的致病因素之一，但其在MS进展中的作用仍不确定。此外，EBV与MS发展的其他风险因素之间的相互作用仍需更多研究投入。与EBV相比，证据不太一致，HHV6也被认为与MS的发病机制有关；此外，它与疾病活动表现出更密切的联系。最近的研究发现，HERV与MS的发展和进展有关。一些抗病毒治疗已显示出有望在未来用于临床干预。未来仍需要进一步研究，以充分阐明这些病原体在MS发病和病程中的作用以及它们实现这些作用的方式。
