Strandberg Louise, Lorentzon Mattias, Hellqvist Asa, Nilsson Staffan, Wallenius Ville, Ohlsson Claes, Jansson John-Olov
Institute of Neuroscience and Physiology/Endocrinology, Sahlgrenska Academy, Göteborg University, P.O. Box 434, SE 405 30 Göteborg, Sweden.
J Clin Endocrinol Metab. 2006 Jul;91(7):2749-54. doi: 10.1210/jc.2005-2786. Epub 2006 Apr 24.
There is growing evidence for interactions between the regulation of body fat and the immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect.
The objective of the study was to investigate our hypothesis that common polymorphisms of the IL-1 system, which are associated with IL-1 activity, also are associated with fat mass. DESIGN, SETTING, AND STUDY SUBJECTS: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-yr-old men (n = 1068), mostly Caucasian, from the Gothenburg area (Sweden). Three different polymorphisms, IL-1beta +3953 C/T, IL-1beta-31 T/C, and IL-1 receptor antagonist (IL-1RN) variable number tandem repeat of 86 bp, were investigated in relation to body fat mass.
The main outcome measures were genotype distributions and their association with body fat mass in different compartments, measured with dual-energy x-ray absorptiometry.
Carriers of the T variant (CT and TT) of the +3953 C to T (F(T) = 0.25) IL-1beta gene polymorphism had significantly lower total fat mass (P = 0.013) and also significantly reduced arm, leg, and trunk fat, compared with CC individuals. IL-1RN*2 carriers with two repeats of the IL-1RN variable number tandem repeat polymorphism had increased total fat (P = 0.036), serum leptin, and fat of trunk and arm as well as serum levels of IL-1RN and IL-1RN production ex vivo. The IL-1beta-31 polymorphism did not correlate with the fat measurements.
The IL-1 system, recently shown to affect fat mass in experimental animals, contains gene polymorphisms that are associated with fat mass in young men.
越来越多的证据表明体脂调节与免疫系统之间存在相互作用。对基因敲除小鼠的研究表明，白细胞介素-1（IL-1）具有抗肥胖作用。
本研究的目的是检验我们的假设，即与IL-1活性相关的IL-1系统常见多态性也与脂肪量相关。
设计、地点和研究对象：哥德堡骨质疏松症和肥胖决定因素（GOOD）研究是一项基于人群的横断面研究，研究对象为来自瑞典哥德堡地区的18至20岁男性（n = 1068），大多数为白种人。研究了三种不同的多态性，即IL-1β +3953 C/T、IL-1β -31 T/C以及86 bp的白细胞介素-1受体拮抗剂（IL-1RN）可变数目串联重复序列，它们与体脂量的关系。
主要观察指标是基因型分布及其与不同部位体脂量的关联，采用双能X线吸收法进行测量。
与CC个体相比，IL-1β基因+3953 C到T（F(T)=0.25）多态性的T变异携带者（CT和TT）的总脂肪量显著降低（P = 0.013），手臂、腿部和躯干脂肪也显著减少。IL-1RN可变数目串联重复多态性有两个重复的IL-1RN*2携带者的总脂肪、血清瘦素、躯干和手臂脂肪以及IL-1RN血清水平和体外IL-1RN产生均增加（P = 0.036）。IL-1β -31多态性与脂肪测量结果无关。
最近在实验动物中显示影响脂肪量的IL-1系统，包含与年轻男性脂肪量相关的基因多态性。
