Onwuteaka-Philipsen Bregje D, Fisher Susanne, Cartwright Colleen, Deliens Luc, Miccinesi Guido, Norup Michael, Nilstun Tore, van der Heide Agnes, van der Wal Gerrit
Department of Social Medicine, VU University Medical Centre, Amsterdam, the Netherlands.
Arch Intern Med. 2006 Apr 24;166(8):921-9. doi: 10.1001/archinte.166.8.921.
The frequencies with which physicians make different medical end-of-life decisions (ELDs) may differ between countries, but comparison between countries has been difficult owing to the use of dissimilar research methods.
A written questionnaire was sent to a random sample of physicians from 9 specialties in 6 European countries and Australia to investigate possible differences in the frequencies of physicians' willingness to perform ELDs and to identify predicting factors. Response rates ranged from 39% to 68% (N = 10 139). Using hypothetical cases, physicians were asked whether they would (probably) make each of 4 ELDs.
In all the countries, 75% to 99% of physicians would withhold chemotherapy or intensify symptom treatment at the request of a patient with terminal cancer. In most cases, more than half of all physicians would also be willing to deeply sedate such a patient until death. However, there was generally less willingness to administer drugs with the explicit intention of hastening death at the request of the patient. The most important predictor of ELDs was a request from a patient with decisional capacity (odds ratio, 2.1-140.0). Shorter patient life expectancy and uncontrollable pain were weaker predictors but were more stable across countries and across the various ELDs (odds ratios, 1.1-2.4 and 0.9-2.4, respectively).
Cultural and legal factors seem to influence the frequencies of different ELDs and the strength of their determinants across countries, but they do not change the essence of decision making.
不同国家的医生做出不同医学临终决策(ELDs)的频率可能存在差异,但由于研究方法不同,国与国之间的比较一直很困难。
向来自6个欧洲国家和澳大利亚9个专业的医生随机样本发送书面问卷,以调查医生做出ELDs意愿频率的可能差异,并确定预测因素。回复率在39%至68%之间(N = 10139)。使用假设案例,询问医生是否会(可能)做出4种ELDs中的每一种。
在所有国家,75%至99%的医生会应晚期癌症患者的要求停止化疗或加强症状治疗。在大多数情况下,超过一半的医生也愿意对这样的患者进行深度镇静直至死亡。然而,一般来说,应患者要求明确有意加速死亡而给药的意愿较低。ELDs的最重要预测因素是有决策能力的患者的请求(优势比,2.1 - 140.0)。患者预期寿命较短和疼痛无法控制是较弱的预测因素,但在不同国家和各种ELDs中更为稳定(优势比分别为1.1 - 2.4和0.9 - 2.4)。
文化和法律因素似乎会影响不同ELDs的频率及其决定因素的强度,但它们不会改变决策的本质。