Hess Markus M, Mueller Frank, Kobler James B, Zeitels Steven M, Goodyer Eric
Department of Phoniatrics and Pediatric Audiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Folia Phoniatr Logop. 2006;58(3):207-16. doi: 10.1159/000091734.
The linear skin rheometer (LSR), which measures skin visco-elasticity, was adapted for measurements of vocal fold properties. A series of studies was performed on animal and human excised larynges to determine if the LSR technique can be applied to the vocal fold.
In excised larynges, small patches of mucosa were driven sinusoidally at 0.3 Hz over distances of 1-2 mm using a small probe. Forces in the order of 1 g equivalent gave optimal measurements. Stiffness and viscosity values were derived from stress/strain data.
The instrument was able to measure the visco-elasticity of the tissue in a repeatable manner and it could detect areas where the tissue was artificially stiffened. Two-dimensional maps of the mechanical properties of the laryngeal mucosa were obtained showing local variations in elasticity both parallel and perpendicular to the vocal fold edge. Initial studies were undertaken using animal tissue; more recently, the LSR has been successfully used to obtain similar data from human tissue.
The LSR was been demonstrated to be capable of measuring the elastic properties of the vocal fold in a repeatable and reliable manner. Further studies will now be undertaken to obtain data from a larger sample of human tissue.
线性皮肤流变仪（LSR）用于测量皮肤的粘弹性，现被改编用于测量声带特性。我们对动物和人类离体喉部进行了一系列研究，以确定LSR技术是否可应用于声带。
在离体喉部，使用一个小探头以0.3赫兹的频率在1 - 2毫米的距离上对小块黏膜进行正弦驱动。约1克当量的力可得到最佳测量结果。刚度和粘度值由应力/应变数据得出。
该仪器能够以可重复的方式测量组织的粘弹性，并且能够检测出组织人为变硬的区域。获得了喉黏膜力学特性的二维图谱，显示了平行和垂直于声带边缘的弹性局部变化。最初的研究使用动物组织；最近，LSR已成功用于从人体组织获取类似数据。
已证明LSR能够以可重复且可靠的方式测量声带的弹性特性。现在将进行进一步研究，以从更大样本的人体组织中获取数据。
