Dahl J, Myhr K-M, Daltveit A K, Gilhus N E
Department of Clinical Medicine, Section of Neurology, University of Bergen and Department of Neurology, Haukeland University Hospital, Norway.
Acta Neurol Scand Suppl. 2006;183:51-4. doi: 10.1111/j.1600-0404.2006.00616.x.
The objective of this study was to investigate the effect of maternal multiple sclerosis (MS) on delivery and birth outcome in births without planned caesarean section.
Data were collected from the compulsory Medical Birth Registry of Norway from 1988 to 2002. Intended vaginal births in this time period were 449 births given by MS mothers and 851,060 control births.
The MS mothers had a higher rate of induction of labour, and there was a strong trend for slower progression of second stage of labour and increased use of forceps. The MS group had lower birth weight and length of the neonates. The frequency of birth defects and the neonatal mortality were not increased in the MS group.
Maternal MS affects the birth process and the neonate prenatally, even when the births with planned caesarean section are excluded. MS-related neuronal dysfunction linked to the uterus, is postulated as the most likely mechanism.
本研究旨在探讨母亲患多发性硬化症（MS）对未计划剖宫产分娩及出生结局的影响。
数据收集自挪威1988年至2002年的强制性医疗出生登记处。在此期间，MS母亲的意向性阴道分娩有449例，对照分娩有851,060例。
MS母亲的引产率较高，且第二产程进展缓慢及产钳使用增加的趋势明显。MS组新生儿出生体重和身长较低。MS组出生缺陷频率和新生儿死亡率未增加。
即使排除计划剖宫产的分娩情况，母亲患MS仍会在产前影响分娩过程和新生儿。与子宫相关的MS相关神经元功能障碍被认为是最可能的机制。
