Dogru Murat, Ishida Katsushi, Matsumoto Yukihiro, Goto Eiki, Ishioka Misaki, Kojima Takashi, Goto Tateki, Saeki Megumi, Tsubota Kazuo
Department of Ophthalmology, Tokyo Dental College, Ichikawa, Japan.
Invest Ophthalmol Vis Sci. 2006 May;47(5):1895-901. doi: 10.1167/iovs.05-0802.
To investigate the applicability and efficacy of a new and simple method of quantification of the volume of tear meniscus, termed "strip meniscometry," in the diagnosis of the dry eye syndromes in a prospective controlled study.
One hundred eyes of 50 patients with dry eye (19 males; 31 females) aged between 18 and 76 years (mean, 54.3 years), as well as 80 eyes of 40 normal subjects aged from 15 to 70 years (mean, 50.8 years; 12 males, 28 females) were recruited in this study. The patients and the control subjects underwent strip meniscometry for 5 seconds, tear film lipid layer interferometry, tear film break-up time measurement, and ocular surface vital staining with fluorescein and rose bengal dyes and the Schirmer-1 test.
Strip meniscometry scores correlated with tear quantity and stability, ocular surface staining scores, and lipid layer interferometry grades and improved after 2 weeks of punctal plug occlusion.
Strip meniscometry is a swift, noninvasive, promising new method that is expected to find application in the diagnosis and evaluation of the outcome of treatment of dry eye syndromes.
在一项前瞻性对照研究中，探讨一种新的、简单的泪液半月皱襞体积定量方法，即“试纸条泪液半月皱襞测量法”，在干眼综合征诊断中的适用性和有效性。
本研究招募了50例年龄在18至76岁（平均54.3岁）的干眼患者（19例男性；31例女性）的100只眼，以及40例年龄在15至70岁（平均50.8岁；12例男性，28例女性）的正常受试者的80只眼。患者和对照受试者接受5秒的试纸条泪液半月皱襞测量、泪膜脂质层干涉测量、泪膜破裂时间测量，以及用荧光素和孟加拉玫瑰红染料进行眼表活体染色和Schirmer-1试验。
试纸条泪液半月皱襞测量分数与泪液量和稳定性、眼表染色分数以及脂质层干涉测量等级相关，并且在泪点栓塞2周后有所改善。
试纸条泪液半月皱襞测量法是一种快速、无创、有前景的新方法，有望应用于干眼综合征的诊断和治疗效果评估。
