Choi Stacey S, Doble Nathan, Hardy Joseph L, Jones Steven M, Keltner John L, Olivier Scot S, Werner John S
Department of Ophthalmology & Vision Science, University of California Davis, Sacramento 95817, USA.
Invest Ophthalmol Vis Sci. 2006 May;47(5):2080-92. doi: 10.1167/iovs.05-0997.
To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy.
The UC Davis Adaptive Optics (AO) fundus camera was used to acquire in vivo retinal images at the cellular level. Visual function tests consisting of visual fields, multifocal electroretinography (mfERG), and contrast sensitivity were measured in all subjects by using stimuli that were coincident with areas imaged. Five patients with different forms of retinal dystrophy and three control subjects were recruited. Cone densities were quantified for all retinal images.
In all images of diseased retinas, there were extensive areas of dark space between groups of photoreceptors, where no cone photoreceptors were evident. These irregular features were not seen in healthy retinas, but were apparent in patients with retinal dystrophy. There were significant correlations between functional vision losses and the extent to which these irregularities, quantified by cone density, occurred in retinal images.
AO fundus imaging is a reliable technique for assessing and quantifying the changes in the photoreceptor layer as disease progresses. Furthermore, this technique can be useful in cases where visual function tests provide borderline or ambiguous results, as it allows visualization of individual photoreceptors.
探讨不同形式视网膜营养不良患者的活体视网膜微观变化与视觉功能之间的关系。
使用加州大学戴维斯分校自适应光学（AO）眼底相机在细胞水平获取活体视网膜图像。通过使用与成像区域重合的刺激，对所有受试者进行包括视野、多焦视网膜电图（mfERG）和对比敏感度在内的视觉功能测试。招募了5名患有不同形式视网膜营养不良的患者和3名对照受试者。对所有视网膜图像的视锥细胞密度进行量化。
在所有患病视网膜图像中，感光细胞群之间存在大片黑暗区域，未见视锥感光细胞。这些不规则特征在健康视网膜中未见，但在视网膜营养不良患者中明显。功能性视力丧失与视网膜图像中通过视锥细胞密度量化的这些不规则程度之间存在显著相关性。
AO眼底成像技术是一种可靠的技术，可用于评估和量化疾病进展过程中感光细胞层的变化。此外，当视觉功能测试结果处于临界或不明确状态时，该技术可能会很有用，因为它可以可视化单个感光细胞。
