Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, via Cassia 600, 00189 Rome, Italy.
Arthritis Res Ther. 2009;11(6):R183. doi: 10.1186/ar2875. Epub 2009 Dec 9.
Comparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip.
A pilot prospective, double-blind, 6-month randomized trial of 42 patients with hip OA. HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety.
Patients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (P < 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (P < 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal.
This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA.
ISRCTN39397064.
比较关节内细菌源性透明质酸（Hyalubrix）（HA）与局部麻醉药（甲哌卡因）治疗髋关节骨关节炎（OA）。
42 例髋关节 OA 患者进行了一项前瞻性、双盲、6 个月随机试验。在超声引导下，HA 或甲哌卡因每两个月（每月一次）给药两次。疗效测量包括 Lequesne 的algofunctional 指数、疼痛视觉模拟评分、同时使用的镇痛药、患者和医生的整体测量以及安全性。
与局部麻醉药组相比，HA 组患者在治疗后 3 个月和 6 个月时 Lequesne 的algofunctional 指数显著降低（P < 0.001），疼痛视觉模拟评分也显著降低（P < 0.05）。与基线相比，所有主要和次要措施均显著改善，但在 3 个月或 6 个月时彼此之间没有差异。不良反应最小。
这项比较研究表明关节内 HA 对髋关节 OA 的治疗具有有益的效果和安全性。
ISRCTN39397064。
