Wolfrath Summer C, Borenstein Amy R, Schwartz Skai, Hauser Robert A, Sullivan Kelly L, Zesiewicz Theresa A
Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence, and Department of Neurology, College of Medicine, University of South Florida, Tampa, Florida, USA.
Mov Disord. 2006 Aug;21(8):1098-101. doi: 10.1002/mds.20902.
The use of nutritional supplements has almost doubled in the elderly population in the United States (US) in the past decade. We evaluated the use of nutritional supplements in Parkinson's disease (PD) patients to determine the prevalence of their use and whether patients were aware of possible side effects and drug interactions in the supplements they were taking. Consecutively selected PD patients from an academic movement disorders center completed a 33-item questionnaire regarding their use of nutritional supplements. A total of 120 PD patients completed the questionnaire and were included in the data analysis (mean age +/- SD = 68.2 +/- 11.65 years, 67 [55.8%] men and 53 women). Seventy-six patients (63%) took nutritional supplements at the time of data collection. Vitamins were the most common nutritional supplements used, and vitamin E was the most commonly used vitamin. Thirty-six patients (47%) who took nutritional supplements consulted with their doctor before taking them, and only 4% of patients who took nutritional supplements were aware of possible side effects from their use. Twenty patients (16.7%) reported that they were currently taking nutritional supplements because of symptoms related to their Parkinson's disease. The vast majority of PD patients surveyed were not aware that nutritional supplements could cause adverse side effects. Less than half of the patients who took nutritional supplements consulted their physician before starting them. Greater awareness of nutritional supplement use in PD patients is warranted to avoid potentially harmful effects and drug interactions.
在过去十年中，美国老年人群体中营养补充剂的使用量几乎翻了一番。我们评估了帕金森病（PD）患者营养补充剂的使用情况，以确定其使用 prevalence 以及患者是否知晓他们所服用补充剂可能存在的副作用和药物相互作用。从一个学术性运动障碍中心连续选取的PD患者完成了一份关于其营养补充剂使用情况的33项问卷。共有120名PD患者完成了问卷并纳入数据分析（平均年龄±标准差 = 68.2±11.65岁，67名[55.8%]男性和53名女性）。在数据收集时，76名患者（63%）服用营养补充剂。维生素是最常用的营养补充剂，维生素E是最常使用的维生素。36名（47%）服用营养补充剂的患者在服用前咨询了医生，而服用营养补充剂的患者中只有4%知晓其使用可能产生的副作用。20名患者（16.7%）报告称他们目前服用营养补充剂是因为与帕金森病相关的症状。绝大多数接受调查的PD患者不知道营养补充剂可能会引起不良副作用。服用营养补充剂的患者中不到一半在开始服用前咨询了医生。有必要提高PD患者对营养补充剂使用的认识，以避免潜在的有害影响和药物相互作用。 （注：“prevalence”在医学研究中常译为“患病率”等，但这里结合语境似乎不太准确，可根据实际情况调整，暂保留英文）
