难治性癫痫患儿营养状况评估
Evaluation of nutritional status in children with refractory epilepsy.
作者信息
Bertoli S, Cardinali S, Veggiotti P, Trentani C, Testolin G, Tagliabue A
机构信息
International Centre for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
出版信息
Nutr J. 2006 Apr 26;5:14. doi: 10.1186/1475-2891-5-14.
BACKGROUND
children affected by refractory epilepsy could be at risk of malnutrition because of feeding difficulties (anorexia, chewing, swallowing difficulties or vomiting) and chronic use of anticonvulsants, which may affect food intake and energy metabolism. Moreover, their energy requirement may be changed as their disabilities would impede normal daily activities. The aim of the present study was to evaluate nutritional status, energy metabolism and food intake in children with refractory epilepsy.
METHODS
17 children with refractory epilepsy (13 boys and 4 girls; mean age 9 +/- 3,2 years; Body Mass Index 15,7 +/- 3,6) underwent an anthropometric assessment, body composition evaluation by dual-energy X-ray absorptiometry, detailed dietetic survey and measurement of resting energy expenditure by indirect calorimetry. Weight-for-age, height-for-age (stunting) and weight-for-height (wasting) were estimated compared to those of a reference population of the same age.
RESULTS
40% of children were malnourished and 24% were wasted. The nutritional status was worse in the more disabled children. Dietary intake resulted unbalanced (18%, 39%, 43% of total daily energy intake derived respectively from protein, lipid and carbohydrate). Adequacy index [nutrient daily intake/recommended allowance (RDA) x 100] was < 60% for calcium iron and zinc.
CONCLUSION
many children with refractory epilepsy would benefit from individual nutritional assessment and management as part of their overall care.
背景
患有难治性癫痫的儿童可能因喂养困难（厌食、咀嚼、吞咽困难或呕吐）以及长期使用抗惊厥药物而面临营养不良的风险，这些药物可能会影响食物摄入和能量代谢。此外，由于他们的残疾会妨碍正常的日常活动，其能量需求可能会发生变化。本研究的目的是评估难治性癫痫儿童的营养状况、能量代谢和食物摄入情况。
方法
17名难治性癫痫儿童（13名男孩和4名女孩；平均年龄9±3.2岁；体重指数15.7±3.6）接受了人体测量评估、通过双能X线吸收法进行身体成分评估、详细的饮食调查以及通过间接测热法测量静息能量消耗。将年龄别体重、年龄别身高（发育迟缓）和身高别体重（消瘦）与同年龄的参考人群进行比较。
结果
40%的儿童营养不良，24%的儿童消瘦。残疾程度较重的儿童营养状况更差。饮食摄入不均衡（每日总能量摄入的18%、39%、43%分别来自蛋白质、脂肪和碳水化合物）。钙、铁和锌的充足指数[营养素每日摄入量/推荐摄入量（RDA）×100]低于60%。
结论
许多难治性癫痫儿童将受益于作为其整体护理一部分的个体营养评估和管理。
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