Tátrai E, Wojnárovits I, Ungváry G
National Institute of Occupational Health, Budapest, Hungary.
Exp Pathol. 1991;43(1-2):41-6. doi: 10.1016/s0232-1513(11)80140-4.
A study was made on the pulmonary pathological reactions after intratracheal introduction of non-fibrous zeolite into CFY rats in long-term sequential investigations (1st week; 1st, 3rd, 6th months and 1st year). After treatment at the end of the 1st week non-specific confluating bronchopneumonia followed by a storage type reaction developed at the end of the 1st month. In the later periods in addition to storage character mild pulmonary fibrosis has been observed. At the end of the 1st year, transmission electron microscopy and X-ray microanalysis verified that aluminium and silicon ratio in zeolite storaged in the macrophages of the lungs was the same as found in natural zeolite (1:6). In the lungs of 3 animals atypical hyperplasia developed; therefore an in vivo study of the carcinogenic effect of non-fibrous zeolite seemed justified.
进行了一项长期连续研究（第1周；第1、3、6个月和第1年），向CFY大鼠气管内注入非纤维状沸石后，观察其肺部病理反应。在第1周结束时进行治疗后，第1个月结束时出现了非特异性融合性支气管肺炎，随后出现了储存型反应。在后期，除了储存特征外，还观察到轻度肺纤维化。在第1年结束时，透射电子显微镜和X射线微分析证实，储存在肺巨噬细胞中的沸石中铝和硅的比例与天然沸石中的比例相同（1:6）。在3只动物的肺部出现了非典型增生；因此，对非纤维状沸石致癌作用进行体内研究似乎是合理的。
